Synthesis and biological study of pyracetam derivatives and related compounds

…, RG Glushkov, LF Roshchina, AI Polezhaeva…

Index: Stezhko, T. V.; Granik, V. G.; Glushkov, R. G.; Roshchina, L. F.; Polezhaeva, A. I.; Mashkovskii, M. D. Pharmaceutical Chemistry Journal, 1984 , vol. 18, # 3 p. 154 - 161 Khimiko-Farmatsevticheskii Zhurnal, 1984 , vol. 18, # 3 p. 290 - 297

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Abstract

Activation of the lactam function of I itself with retention of the carbamido group is hardly possible. It therefore seemed expedient to use l-cyanomethyl-2-pyrrolidone (II)~ as the starting compound; the 1 position of this lactam contains a small cyanomethyl substituent, ...