Research on Chemical Intermediates

New synthesis of 2-benzimidazoleacetates and study of their Knoevenagel reaction

PH Yang, QZ Zhang, HJ Yu

Index: Yang, Peng Hui; Zhang, Qun Zheng; Yu, Hong Jiang Research on Chemical Intermediates, 2012 , vol. 38, # 7 p. 1403 - 1409

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Abstract

Abstract To obtain 2-benzimidazolyl acrylate 2, a new efficient synthesis of 2- benzimidazoleacetate, involving esterification of 2-benzimidazole acetic acid at low temperature as the crucial step, was developed. The generality and efficiency of the process was illustrated by the high-yield synthesis of methyl, ethyl, i-propyl, and n-butyl 2- benzimidazoleacetate. The Knoevenagel reaction of 2-benzimidazoleacetate with ...