Effect of reactivity on virtual transition-state structure for the acylation stage of acetylcholinesterase-catalyzed hydrolysis of aryl esters and anilides

…, PN Barlow, GC Lee, ML Swanson…

Index: Acheson, Scott A.; Barlow, Paul N.; Lee, Gerald C.; Swanson, Michael L.; Quinn, Daniel M. Journal of the American Chemical Society, 1987 , vol. 109, # 1 p. 246 - 252

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Citation Number: 15

Abstract

Abstract: The acylation stage of acetylcholinesterase-catalyzed hydrolysis of p- methoxyphenyl formate and of three anilides (0-nitrochloroacetanilide, o-nitroacetanilide, and o-nitroformanilide) has been studied by measuring substrate secondary and solvent isotope effects and by determining pL (L= H, D)-rate profiles and Eyring plots. The results of each of these probes support a model for acylation rate determination that involves a ...

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