Antiviral agents. 2. Structure-activity relations of compounds related to 1-adamantanamine

…, EC Hermann, WE Meier, M Paulshock…

Index: Aldrich; Hermann; Meier; Paulshock; Prichard; Snyder; Watts Journal of medicinal chemistry, 1971 , vol. 14, # 6 p. 535 - 543

Full Text: HTML

Citation Number: 85

Abstract

(6) IT. L. Wingfield, D. Pollack, and RR Grunert, N. Enol. J. Med., a81, 579 (1969). and with rimantadine-HC16 (a-methyl-l-adamantanemethylamine. HC1, 58) in patients with naturally occurring influenza A2 respiratory illness. Inhibition of rubella,'Rous~ arcoma,~~~ and Esh sarcoma viruses has also been reported. Amantadine'HC1 more recently has been demonstrated to benefit patients suffering from Parkinson's disease. lo Meanwhile, others" ...

 Related Synthetic Route
ETHYLENE OXIDE Structure

75-21-8

ETHYLENE OXIDE

1-Adamantanamine hydrochloride Structure

665-66-7

1-Adamantanamin...

~%

2-[1-adamantyl(2-hydroxyethyl)amino]ethanol Structure

3716-67-4

2-[1-adamantyl(...

Formaldehyde Structure

50-00-0

Formaldehyde

1-Adamantanamine hydrochloride Structure

665-66-7

1-Adamantanamin...

~%

1-Adamantyldimethylamine Structure

3717-40-6

1-Adamantyldime...

2-[1-adamantyl(2-hydroxyethyl)amino]ethanol Structure

3716-67-4

2-[1-adamantyl(...

~%

amantadine-N-mustard Structure

5592-71-2

amantadine-N-mustard

1-Adamantanamine hydrochloride Structure

665-66-7

1-Adamantanamin...

~%

amantadine-N-mustard Structure

5592-71-2

amantadine-N-mustard

ETHYLENE OXIDE Structure

75-21-8

ETHYLENE OXIDE

1-Adamantanamine hydrochloride Structure

665-66-7

1-Adamantanamin...

~%

2-(1-Adamantylamino)ethanol Structure

3716-66-3

2-(1-Adamantyla...

1-Bromoadamantane Structure

768-90-1

1-Bromoadamantane

methylamine Structure

74-89-5

methylamine

~%

N-Methyl-1-adamantanamine Structure

3717-38-2

N-Methyl-1-adam...

1-Adamantyl isocyanate Structure

4411-25-0

1-Adamantyl iso...

~%

N-(1-ADAMANTYL)HYDRAZINECARBOXAMIDE Structure

26496-36-6

N-(1-ADAMANTYL)...

1-Bromoadamantane Structure

768-90-1

1-Bromoadamantane

isopropylamine Structure

75-31-0

isopropylamine

~%

N-propan-2-yladamantan-1-amine Structure

3667-90-1

N-propan-2-ylad...

(1-Adamantyl)carbamidsaeure-methylester Structure

59987-81-4

(1-Adamantyl)ca...

~%

N-Ethyladamantan-1-amine hydrochloride Structure

3717-44-0

N-Ethyladamanta...

Aziridine Structure

151-56-4

Aziridine

Adamantan-1-amine Structure

768-94-5

Adamantan-1-amine

~%

N-(Adamantan-1-yl)-1,2-ethanediamine Structure

37818-93-2

N-(Adamantan-1-...

N/A Structure

26525-23-5

N/A

~%

adapromine Structure

60196-90-9

adapromine

1-(2-Azidoethyl)adamantane Structure

26831-49-2

1-(2-Azidoethyl...

~%

1-adamantaneethanamine Structure

26482-53-1

1-adamantaneeth...

1-(2-bromoethyl)adamantane Structure

773-37-5

1-(2-bromoethyl...

~%

1-adamantaneethanamine Structure

26482-53-1

1-adamantaneeth...

[Re(CH3NHNH2)(CO)(P(OEt)3)4](1+) Structure

4546-46-7

[Re(CH3NHNH2)(C...

~%

Tricyclo[4.3.1.13,8]undecan-3-amine Structure

3048-63-3

Tricyclo[4.3.1....

Tricyclo[4.3.1.13,8]undecane-3-carboxylic acid Structure

21898-91-9

Tricyclo[4.3.1....

~%

Tricyclo[4.3.1.13,8]undecan-3-amine Structure

3048-63-3

Tricyclo[4.3.1....

1-Bromoadamantane Structure

768-90-1

1-Bromoadamantane

Structure

74497-02-2

~%

Tricyclo[3.3.1.13,7]decan-1-amine,N-phenyl- Structure

33187-62-1

Tricyclo[3.3.1....


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