The asymmetric alkylation of carbonyl compounds is one of the most important methods for generating stereocenters in organic synthesis.[1] The alkylation of ester enolates is particularly useful as the resulting products can be converted into a variety of carboxylic acid derivatives or reduced to alcohols without loss of enantioenrichment at the α center.[2] The most common procedures for asymmetric ester enolate alkylations, however, involve the ...
