A series of 3-[[(aryloxy) alkyllpiperidinyll-l, 2-benzisoxazoles was synthesized and evaluated as potential antipsychotic Dd5-HTz antagonists. Most of these compounds showed potent antipsychotic-like activity in an apomorphine-induced climbing mouse paradigm, with many also showing preferential mesolimbic activity, as indicated by their weaker effects in an apomorphine-induced stereotypy model. In receptor binding assays, many displayed a ...
