3-[[(Aryloxy) alkyl] piperidinyl]-1, 2-benzisoxazoles as D2/5-HT2 antagonists with potential atypical antipsychotic activity: antipsychotic profile of iloperidone (HP 873)

JT Strupczewski, KJ Bordeau, Y Chiang…

文献索引：Strupczewski; Bordeau; Chiang; Glamkowski; Conway; Corbett; Hartman; Szewczak; Wilmot; Helsley Journal of Medicinal Chemistry, 1995 , vol. 38, # 7 p. 1119 - 1131

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被引用次数: 72

摘要

A series of 3-[[(aryloxy) alkyllpiperidinyll-l, 2-benzisoxazoles was synthesized and evaluated as potential antipsychotic Dd5-HTz antagonists. Most of these compounds showed potent antipsychotic-like activity in an apomorphine-induced climbing mouse paradigm, with many also showing preferential mesolimbic activity, as indicated by their weaker effects in an apomorphine-induced stereotypy model. In receptor binding assays, many displayed a ...