Tetrahedron letters

Efficient method for the direct preparation of amides from carboxylic acids using tosyl chloride under solvent-free conditions

A Khalafi-Nezhad, A Parhami, MNS Rad, A Zarea

Index: Khalafi-Nezhad, Ali; Parhami, Abolfath; Soltani Rad, Mohammad Navid; Zarea, Abdolkarim Tetrahedron Letters, 2005 , vol. 46, # 40 p. 6879 - 6882

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Citation Number: 53

Abstract

A simple, clean and highly efficient solvent-free procedure for the preparation of primary, secondary, tertiary and aromatic amides is described from the direct reaction of carboxylic acids and silica-supported ammonium salts, triethylamine (TEA) and tosyl chloride (TsCl) as condensing agent. The reaction proceeds rapidly in high yields at room temperature.

~80%

~87%

~73%

~90%

~78%

~90%

~90%

~77%

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