Direct oxidative Heck cyclizations: intramolecular Fujiwara–Moritani arylations for the synthesis of functionalized benzofurans and dihydrobenzofurans

H Zhang, EM Ferreira, BM Stoltz

Index: Zhang, Haiming; Ferreira, Eric M.; Stoltz, Brian M. Angewandte Chemie - International Edition, 2004 , vol. 43, # 45 p. 6144 - 6148

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Citation Number: 181

Abstract

Over the past two and a half decades, the intramolecular Heck reaction has proven to be an integral process for the formation of CÀC linkages in the synthesis of complex molecules.[1] While the reaction provides desirable products by the coupling of an aryl or vinyl halide with an olefin by extrusion of the hydrohalic acid, the overall process involves two discrete functionalization events: 1) halogenation of an aryl or vinyl precursor and 2) palladium (0)- ...