3, 5-Disubstituted-thiazolidine-2, 4-dione analogs as anticancer agents: design, synthesis and biological characterization

K Liu, W Rao, H Parikh, Q Li, TL Guo, S Grant…

Index: Liu, Kai; Rao, Wei; Parikh, Hardik; Li, Qianbin; Guo, Tai L.; Grant, Steven; Kellogg, Glen E.; Zhang, Shijun European Journal of Medicinal Chemistry, 2012 , vol. 47, # 1 p. 125 - 137

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Citation Number: 26

Abstract

A series of 2, 5-disubstituted-thiazolidine-2, 4-dione analogs based on the newly identified lead 1, a potential anticancer agent via the inhibition of the Raf/MEK/extracellular signal regulated kinase (ERK) and phosphatidylinositol 3-kinase (PI3K)/Akt signaling cascades, were synthesized and biologically characterized. A new lead structure, 15, was identified to have improved anti-proliferative activities in U937 cells, to induce apoptosis in U937, M12 ...