Chemical Communications

Pd-catalyzed cascade Heck–Saegusa: direct synthesis of enals from aryl iodides and allyl alcohol

J Liu, J Zhu, H Jiang, W Wang, J Li

Index: Liu, Jie; Zhu, Jin; Jiang, Hualiang; Wang, Wei; Li, Jian Chemical Communications, 2010 , vol. 46, # 3 p. 415 - 417

Full Text: HTML

Citation Number: 17

Abstract

Recently, we have developed a novel amine–Pd(OAc) 2 co-catalyzed direct Saegusa oxidation reaction of unmodified β-aryl aldehydes to α,β-unsaturated aldehydes (Scheme 1, eqn (1)). 13 In our continuing efforts aimed at developing more efficient synthetic tools toward the highly valuable building blocks, we questioned whether it might be possible to merge the widely used Heck reaction with the direct Saegusa oxidation process to create a new one-pot approach to these ...