Antitumor activity of bis (diphenylphosphino) alkanes, their gold (I) coordination complexes, and related compounds

…, LF Faucette, FL McCabe, GR Girard…

Index: Mirabelli; Hill; Faucette; McCabe; Girard; Bryan; Sutton; O'Leary Bartus; Crooke; Johnson Journal of Medicinal Chemistry, 1987 , vol. 30, # 12 p. 2181 - 2190

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Citation Number: 149

Abstract

Bisphosphines related to bis (dipheny1phosphino) ethane (dppe) and their gold complexes are described that are active in a spectrum of tiansplantable tumor models. When administered ip on days 1-5 at its maximally tolerated dose (MTD) of 40 pmol/kg, dppe reproducibly gives 100% increase in life span (ILS) in mice bearing ip P388 leukemia. Coordination of chlorogold (1) to each phosphine in dppe gave a complex that had similar ...