Improved Preparation of 4, 6, 6??Trimethyl??1, 3, 2??dioxaborinane and Its Use in a Simple [PdCl2 (TPP) 2]??Catalyzed Borylation of Aryl Bromides and Iodides

N PraveenGanesh, PY Chavant

Index: PraveenGanesh, Nageswaran; Chavant, Pierre Yves European Journal of Organic Chemistry, 2008 , # 27 p. 4690 - 4696

Full Text: HTML

Citation Number: 17

Abstract

Abstract We describe a convenient preparation of 4, 6, 6-trimethyl-1, 3, 2-dioxaborinane ( MethylPentaneDiolBorane, MPBH) and demonstrate that it is an excellent reagent for the [PdCl 2 (PPh 3) 2]-catalyzed borylation of aryl bromides and iodides. The corresponding boronic esters undergo rapid Suzuki coupling reactions in the presence of cesium fluoride. Thus, MPBH is an excellent alternative to pinacolborane for Pd-catalyzed borylation and ...