Highly Efficient One-Pot, Three-Component Synthesis of β-Aminoketones Catalyzed by Fe (O2CCF3) 3

M Zhang, B Xiong, W Yang, L Chen, F Wu…

Index: Zhang, Min; Xiong, Biao; Yang, Wei; Chen, Ling; Wu, Feng; Wang, Quan; Ding, Yuqiang Synthetic Communications, 2012 , vol. 42, # 19 p. 2831 - 2843

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Abstract

A highly efficient one-pot, three-component synthesis of β-aminoketones was demonstrated using the cost-effective, noncorrosive, and easily available Fe(O 2 CCF 3 ) 3 as a catalyst for the first time. The method can be employed to synthesize a wide range of target compounds and to introduce different functional groups into the β-aminoketone skeleton. Additionally, the method consistently has the advantages of good yields, short reaction time, and simply experimental workup ...