Chemistry Letters

Highly Selective Methods for α-Alkenylation and α-Arylation of Ketones via Palladium-or Nickel-Catalyzed Cross Coupling

E Negishi, K Akiyoshi

Index: Negishi, Ei-ichi; Akiyoshi, Kazunari Chemistry Letters, 1987 , p. 1007 - 1010

Full Text: HTML

Citation Number: 20

Abstract

Two procedures for α-alkenylation and α-arylation of ketones, that permit, for the first time, introduction of a stereo-defined alkenyl group (E or Z) in the α-position of cyclic ketones in high yields with essentially complete retention (> 98%) of the alkenyl stereochemistry are reported. Furthermore, the one that is represented by Eq. 2 permits complete control of regiochemistry as well.