Tetrahedron letters

Uncatalyzed aldol reaction using a dimethylsilyl enolate and α-dimethylsilyl ester in N, N-dimethylformamide

K Miura, H Sato, K Tamaki, H Ito, A Hosomi

Index: Miura, Katsukiyo; Sato, Hiroshi; Tamaki, Kentaro; Ito, Hajime; Hosomi, Akira Tetrahedron Letters, 1998 , vol. 39, # 17 p. 2585 - 2588

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Citation Number: 38

Abstract

Dimethylsilyl enolates and α-dimethylsilyl esters reacted with aldehydes in N, N- dimethylformamide without an activator to give aldol adducts in moderate to good yields. Under the same conditions, the corresponding trimethylsilyl derivatives exhibited lower reactivities toward the aldol reaction.