An improved method for the palladium cross-coupling reaction of oxazol-2-ylzinc derivatives with aryl bromides

…, SA Hoover, RJ Imbordino, JJ Pangborn

Index: Reeder, Michael R.; Gleaves, Harold E.; Hoover, Sheree A.; Imbordino, Rick J.; Pangborn, Jeffrey J. Organic Process Research and Development, 2003 , vol. 7, # 5 p. 696 - 699

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Citation Number: 38

Abstract

An improved and scalable procedure to couple ozaxole and thiazole to aryl halides has been demonstrated. The required organozinc reagents were prepared from the aryllithium and solid ZnCl2. These reagents have been successfully coupled to a variety of aryl bromides and aryl iodides in good to excellent yields.