4-Amino-6-arylmethyl/tert-butyl-3-mercapto-1, 2, 4-triazin-5 (4H)-ones (1) were condensed with arylfuroic acids (2) to yield 7-(5-aryl-2-furyl)-3-arylmethyl/tert-butyl-4H-1, 3, 4-thiadiazolo [2, 3-c]-1, 2, 4-triazin-4-ones (3). The newly synthesized compounds exhibited antibacterial activity comparable to that of nitrofurazone. In addition, two compounds displayed in vitro antitumor activity with moderate growth inhibition against a panel of 60 tumor cell lines.
