e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521

Potential salicylamide antiplaque agents: in vitro antibacterial activity against Actinomyces viscosus

RA Coburn, AJ Batista, RT Evans…

Index: Coburn; Batista; Evans; Genco Journal of Medicinal Chemistry, 1981 , vol. 24, # 10 p. 1245 - 1249

Full Text: HTML

Citation Number: 28

Abstract

A series of 55 salicylamides, including 3, 5-dibromo-, 5-n-alkyl-, and 5-n-acylsalicyloyl derivatives of various anilines, heterocyclic amines, benzylamines, and alkylamines, was synthesized and evaluated for in vitro antibacterial activity against Actinomyces uiscosus, an adherent oral microorganism implicated in periodontal disease. The in vitro minimum inhibitory concentrations of 15 4'-bromosalicylanilides were found to correlate (r= 0.92) ...

3,5-Dibromosalicylic acid Structure

3,5-Dibromosali...

~%

Benzamide,3,5-dibromo-2-hydroxy-N-[3-(trifluoromethyl)phenyl]- Structure

Benzamide,3,5-d...

2-Hydroxy-5-octanoylbenzoic acid Structure

2-Hydroxy-5-oct...

~%

salifluor Structure

methyl 2-hydroxy-5-octanoylbenzoate Structure

methyl 2-hydrox...

~%

salifluor Structure

Octanoyl chloride Structure

Octanoyl chloride

~%

salifluor Structure

Methyl salicylate Structure

Methyl salicylate

~%

salifluor Structure

3,5-dibromo-2-hydroxybenzoyl chloride Structure

3,5-dibromo-2-h...

3-(Trifluoromethyl)aniline Structure

3-(Trifluoromet...

~%

Benzamide,3,5-dibromo-2-hydroxy-N-[3-(trifluoromethyl)phenyl]- Structure

Benzamide,3,5-d...

5-Methylsalicylic acid Structure

5-Methylsalicyl...

~%

2-hydroxy-5-methylbenzoyl chloride Structure

2-hydroxy-5-met...

Hexanoyl chloride TOP1 supplier Structure

Hexanoyl chlori...

~%

5-hexyl-2-hydroxybenzoic acid Structure

5-hexyl-2-hydro...

Methyl salicylate Structure

Methyl salicylate

~%

5-hexyl-2-hydroxybenzoic acid Structure

5-hexyl-2-hydro...

N/A Structure

~%

5-hexyl-2-hydroxybenzoic acid Structure

5-hexyl-2-hydro...

5-Bromo-2-hydroxybenzoic acid Structure

5-Bromo-2-hydro...

~%

Benzamide,5-bromo-N-(4-bromophenyl)-2-hydroxy- Structure

Benzamide,5-bro...

Benzoyl chloride, 5-bromo-2-hydroxy- Structure

Benzoyl chlorid...

4-Bromoaniline Structure

~%

Benzamide,5-bromo-N-(4-bromophenyl)-2-hydroxy- Structure

Benzamide,5-bro...

methyl 2-hydroxy-5-octanoylbenzoate Structure

methyl 2-hydrox...

~90%

2-Hydroxy-5-octanoylbenzoic acid Structure

2-Hydroxy-5-oct...

Octanoyl chloride Structure

Octanoyl chloride

~%

2-Hydroxy-5-octanoylbenzoic acid Structure

2-Hydroxy-5-oct...

Methyl salicylate Structure

Methyl salicylate

~%

2-Hydroxy-5-octanoylbenzoic acid Structure

2-Hydroxy-5-oct...

Salicylic acid, 5-nitro- Structure

Salicylic acid,...

~%

Benzamide,N-(4-bromophenyl)-2-hydroxy-5-nitro- Structure

Benzamide,N-(4-...

2-hydroxy-5-nitrobenzoyl chloride Structure

2-hydroxy-5-nit...

4-Bromoaniline Structure

~%

Benzamide,N-(4-bromophenyl)-2-hydroxy-5-nitro- Structure

Benzamide,N-(4-...

3,5-Dibromosalicylic acid Structure

3,5-Dibromosali...

~%

Benzamide,3,5-dibromo-N-[(4-chlorophenyl)methyl]-2-hydroxy- Structure

Benzamide,3,5-d...

3,5-dibromo-2-hydroxybenzoyl chloride Structure

3,5-dibromo-2-h...

4-Chlorobenzylamine Structure

4-Chlorobenzylamine

~%

Benzamide,3,5-dibromo-N-[(4-chlorophenyl)methyl]-2-hydroxy- Structure

Benzamide,3,5-d...

Salicylic acid Structure

~%

Benzamide,N-(4-bromophenyl)-2-hydroxy- Structure

Benzamide,N-(4-...

4-Bromoaniline Structure

Benzoyl chloride,2-hydroxy- Structure

Benzoyl chlorid...

~%

Benzamide,N-(4-bromophenyl)-2-hydroxy- Structure

Benzamide,N-(4-...

2-hydroxy-5-butyryl-benzoic acid methyl ester Structure

2-hydroxy-5-but...

~%

5-butyl-2-hydroxy-N-[3-(trifluoromethyl)phenyl]benzamide Structure

5-butyl-2-hydro...

N/A Structure

~%

5-butyl-2-hydroxy-N-[3-(trifluoromethyl)phenyl]benzamide Structure

5-butyl-2-hydro...

Methyl salicylate Structure

Methyl salicylate

~%

5-butyl-2-hydroxy-N-[3-(trifluoromethyl)phenyl]benzamide Structure

5-butyl-2-hydro...

5-hexyl-2-hydroxybenzoic acid Structure

5-hexyl-2-hydro...

~%

5-hexyl-2-hydroxy-N-(4-nitrophenyl)benzamide Structure

5-hexyl-2-hydro...

N/A Structure

~%

5-hexyl-2-hydroxy-N-(4-nitrophenyl)benzamide Structure

5-hexyl-2-hydro...

methyl 5-hexanoyl-2-hydroxybenzoate Structure

methyl 5-hexano...

~%

5-hexyl-2-hydroxy-N-(4-nitrophenyl)benzamide Structure

5-hexyl-2-hydro...

Hexanoyl chloride TOP1 supplier Structure

Hexanoyl chlori...

~%

5-hexyl-2-hydroxy-N-(4-nitrophenyl)benzamide Structure

5-hexyl-2-hydro...

Methyl salicylate Structure

Methyl salicylate

~%

5-hexyl-2-hydroxy-N-(4-nitrophenyl)benzamide Structure

5-hexyl-2-hydro...

Octanoyl chloride Structure

Octanoyl chloride

~%

2-hydroxy-5-octylbenzoic acid Structure

2-hydroxy-5-oct...

Methyl salicylate Structure

Methyl salicylate

~%

2-hydroxy-5-octylbenzoic acid Structure

2-hydroxy-5-oct...

methyl 2-hydroxy-5-octanoylbenzoate Structure

methyl 2-hydrox...

~%

2-hydroxy-5-octylbenzoic acid Structure

2-hydroxy-5-oct...