(3R)-3-Amino-4-(2, 4, 5-trifluorophenyl)-N-{4-[6-(2-methoxyethoxy) benzothiazol-2-yl] tetrahydropyran-4-yl} butanamide as a potent dipeptidyl peptidase IV inhibitor for …

…, T Ohyama, M Satoh, J Nakaki, S Satoh, C Inada…

Index: Nitta, Aiko; Fujii, Hideaki; Sakami, Satoshi; Nishimura, Yutaka; Ohyama, Tomofumi; Satoh, Mikiya; Nakaki, Junko; Satoh, Shiho; Inada, Chifumi; Kozono, Hideki; Kumagai, Hiroki; Shimamura, Masahiro; Fukazawa, Tominaga; Kawai, Hideki Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 20 p. 5435 - 5438

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Citation Number: 31

Abstract

Novel series of 3-amino-N-(4-aryl-1, 1-dioxothian-4-yl) butanamides and 3-amino-N-(4- aryltetrahydropyran-4-yl) butanamides were synthesized and evaluated as dipeptidyl peptidase IV (DPP-IV) inhibitors. Derivatives incorporating the 6-substituted benzothiazole group showed highly potent DPP-IV inhibitory activity. Oral administration of (3R)-3-amino-4- (2, 4, 5-trifluorophenyl)-N-{4-[6-(2-methoxyethoxy) benzothiazol-2-yl] tetrahydropyran-4-yl} ...