In search of simplicity and flexibility: A rational access to twelve fluoroindolecarboxylic acids

M Schlosser, A Ginanneschi…

Index: Schlosser, Manfred; Ginanneschi, Assunta; Leroux, Frederic European Journal of Organic Chemistry, 2006 , # 13 p. 2956 - 2969

Full Text: HTML

Citation Number: 21

Abstract

Abstract All twelve indolecarboxylic acids 1–12 carrying both a fluorine substituent and a carboxy group at the benzo ring have been prepared either directly from the corresponding fluoroindoles 13–16 or from the chlorinated derivatives 22, 23 and 25 by hydrogen/metal permutation (“metalation”), or from the bromo-or iodofluoroindoles 17–20 and 26, 27, 29 and 30 by halogen/metal permutation, the organometallic intermediate being each time ...

 Related Synthetic Route

~90%

Learn More

~%

Learn More

~%

Learn More

~%

Learn More

~54%

Learn More

~87%

Learn More

~%

Learn More

~%

Learn More

~%

Learn More

~%

Learn More

~74%

Learn More

~37%

Learn More

~63%

Learn More

~%

Learn More

~%

Learn More

~%

Learn More

~%

Learn More

~92%

Learn More

~34%

Learn More

~75%

Learn More

~47%

Learn More

~48%

Learn More

~%

Learn More

~%

Learn More

~%

Learn More

~%

Learn More

~59%

Learn More

~%

Learn More

~%

Learn More

~%

Learn More

~56%

Learn More

~71%

Learn More

~32%

Learn More