Cell permeability as a parameter for lead generation in the protein Tyrosine kinase inhibition field

C Papageorgiou, G Camenisch, X Borer

Index: Papageorgiou, Christos; Camenisch, Gian; Borer, Xaver Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 12 p. 1549 - 1552

Full Text: HTML

Citation Number: 17

Abstract

Based on the inverse relationship between polar surface area and cell permeability and capitalizing on the properties of pyrrolopyrimidines 1 as protein tyrosine kinase inhibitors, pyrrolopyridones 2 were designed and synthesized as potential leads for the development ...