Sleep-inducing N-alkyl-5-[m-(trifluoromethyl) phenyl]-5-hydroxy-2-pyrrolidinones and N-alkyl-3-(trifluoromethyl) cinnamamides

WJ Houlihan, JH Gogerty, EA Ryan…

Index: Houlihan, William J.; Gogerty, John H.; Ryan, Eileen A.; Schmitt, Gemma Journal of Medicinal Chemistry, 1985 , vol. 28, # 1 p. 28 - 31

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Citation Number: 13

Abstract

Pharmacology. All derivatives of IV, V, and VI1 were submitted to a battery of behavioral and drug-interaction test^'^^ in mice that have been used in our laboratories to detect compounds with potential CNS activity. The results of these tests are shown in Tables I and 11. Anticonvulsant activity was measured by determining the antagonism to N- sulfamoylhexahydroazepineg (N-SA). General CNS-depressant activity was defined by ...