Synthetic Communications®

Straightforward Conversion of Alcohols into Nitriles

A Tarrade-Matha, F Pillon, E Doris

Index: Tarrade-Matha, Aurelie; Pillon, Florence; Doris, Eric Synthetic Communications, 2010 , vol. 40, # 11 p. 1646 - 1649

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Abstract

View all references ] Several methods have been developed for this purpose. The classical two-step procedure requires the initial conversion of the hydroxyl group into a leaving group (eg, halide or sulfonate), followed by nucleophilic displacement of the latter with cyanide ions. [ 2 2. Kornblum , N. ; Smiley , RA ; Blackwood , RK ; Iffland , DC The mechanism of the reaction of silver nitrite with alkyl halides: The contrasting reactions of silver and alkali metal salts ...