Synthetic Communications

Efficient and Selective Demethylation of Heteroaryl Methyl Ethers in the Presence of Aryl Methyl Ethers

A Soni, A Dutt, V Sattigeri, IA Cliffe

Index: Soni, Ajay; Dutt, Akhilesh; Sattigeri, Viswajanani; Cliffe, Ian A. Synthetic Communications, 2011 , vol. 41, # 12 p. 1852 - 1857

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Citation Number: 4

Abstract

Abstract A new and efficient method for the demethylation of 6-membered aza-heterocyclic methyl ethers is described using lithium chloride and para-toluenesulfonic acid. This process is chemoselective for aza-heterocyclic methyl ethers in the presence of aryl methyl ethers.

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