Synthetic Communications

Efficient and Selective Demethylation of Heteroaryl Methyl Ethers in the Presence of Aryl Methyl Ethers

A Soni, A Dutt, V Sattigeri, IA Cliffe

文献索引：Soni, Ajay; Dutt, Akhilesh; Sattigeri, Viswajanani; Cliffe, Ian A. Synthetic Communications, 2011 , vol. 41, # 12 p. 1852 - 1857

全文：HTML全文

被引用次数: 4

摘要

Abstract A new and efficient method for the demethylation of 6-membered aza-heterocyclic methyl ethers is described using lithium chloride and para-toluenesulfonic acid. This process is chemoselective for aza-heterocyclic methyl ethers in the presence of aryl methyl ethers.

~83%

~10%

Formal radical closure onto aromatic rings—a general route t...

[Clive, Derrick L. J.; Sunasee, Rajesh; Chen, Zhenhua Organic and Biomolecular Chemistry, 2008 , vol. 6, # 13 p. 2434 - 2441]

Metal-free oxidation of aromatic carbon-hydrogen bonds throu...

[Nature, , vol. 499, # 7457 p. 192 - 196]

Discovery and development of organic super-electron-donors

[Jolly, Phillip I.; Fleary-Roberts, Nadia; O'Sullivan, Steven; Doni, Eswararao; Zhou, Shengze; Murphy, John A. Organic and Biomolecular Chemistry, 2012 , vol. 10, # 30 p. 5807 - 5810]

Annelation reactions of 3-phenylthiobut-3-en-2-one. A new me...

[Takaki, Ken; Okada, Michikazu; Yamada, Michio; Negoro, Kenji Journal of the Chemical Society, Chemical Communications, 1980 , # 24 p. 1183 - 1184]

Formal radical closure onto aromatic rings—a general route t...

[Clive, Derrick L. J.; Sunasee, Rajesh; Chen, Zhenhua Organic and Biomolecular Chemistry, 2008 , vol. 6, # 13 p. 2434 - 2441]