e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521

Structure-activity relationships in a series of xanthine derivatives with antibronchoconstrictory and bronchodilatory activities

…, ML Vericat, J Bartroli, J Garcia-Rafanell, J Forn

Index: Merlos; Gomez; Vericat; Bartroli; Garcia-Rafanell; Forn European Journal of Medicinal Chemistry, 1990 , vol. 25, # 8 p. 653 - 658

Full Text: HTML

Citation Number: 17

Abstract

Abstract Thirty-one 1, 3, 7, 8-substituted xanthine derivatives have been synthesized and evaluated for bronchodilator and antibronchoconstrictory activities in in vitro tracheal relaxation and in vivo bronchospasm inhibition models. Activity tests have been complemented with phosphodiesterase inhibition and toxicological data. Structure-activity relationships are discussed. Compound 21 (1, 3-diisobutyl-8-methylxanthine) has been ...

1-benzyl-3-methyl-urea Structure

1-benzyl-3-meth...

Cyanoacetic acid Structure

Cyanoacetic acid

~%

6-AMINO-1-BENZYL-3-METHYLPYRIMIDINE-2,4(1H,3H)-DIONE Structure

6-AMINO-1-BENZY...

6-amino-1-butyl-3-methyl-5-nitrosopyrimidine-2,4(1H,3H)-dione Structure

6-amino-1-butyl...

~%

5,6-diamino-1-butyl-3-methylpyrimidine-2,4-dione Structure

5,6-diamino-1-b...

6-AMINO-1-BUTYL-3-METHYL-1H-PYRIMIDINE-2,4-DIONE Structure

6-AMINO-1-BUTYL...

~%

5,6-diamino-1-butyl-3-methylpyrimidine-2,4-dione Structure

5,6-diamino-1-b...

Urea,N-butyl-N'-methyl- Structure

Urea,N-butyl-N'...

~%

5,6-diamino-1-butyl-3-methylpyrimidine-2,4-dione Structure

5,6-diamino-1-b...

1-Methyl-3-isobutyl-4-aminouracil Structure

1-Methyl-3-isob...

~%

Xanthine, 1,8-dimethyl-3-isobutyl- Structure

Xanthine, 1,8-d...

1-methyl-3-(2-methylpropyl)urea Structure

1-methyl-3-(2-m...

~%

Xanthine, 1,8-dimethyl-3-isobutyl- Structure

Xanthine, 1,8-d...

6-amino-3-methyl-1-(2-methylpropyl)-5-nitrosopyrimidine-2,4-dione Structure

6-amino-3-methy...

~%

Xanthine, 1,8-dimethyl-3-isobutyl- Structure

Xanthine, 1,8-d...

5,6-diamino-3-methyl-1-(2-methylpropyl)pyrimidine-2,4-dione Structure

5,6-diamino-3-m...

acetic acid Structure

~%

Xanthine, 1,8-dimethyl-3-isobutyl- Structure

Xanthine, 1,8-d...

Urea,N-butyl-N'-methyl- Structure

Urea,N-butyl-N'...

Cyanoacetic acid Structure

Cyanoacetic acid

~%

6-AMINO-1-BUTYL-3-METHYL-1H-PYRIMIDINE-2,4-DIONE Structure

6-AMINO-1-BUTYL...

1-methyl-3-(2-methylpropyl)urea Structure

1-methyl-3-(2-m...

~%

5,6-diamino-3-methyl-1-(2-methylpropyl)pyrimidine-2,4-dione Structure

5,6-diamino-3-m...

1,3-diisobutyl-4-aminouracil Structure

1,3-diisobutyl-...

~%

1,3-Diisobutyl-8-methylxanthine Structure

1,3-Diisobutyl-...

1,3-diisobutyl-4,5-diaminouracil Structure

1,3-diisobutyl-...

acetic acid Structure

~%

1,3-Diisobutyl-8-methylxanthine Structure

1,3-Diisobutyl-...

1,3-bis(2-methylpropyl)urea Structure

1,3-bis(2-methy...

~%

1,3-Diisobutyl-8-methylxanthine Structure

1,3-Diisobutyl-...

1,3-diisobutyl-4-amino-5-nitrosouracil Structure

1,3-diisobutyl-...

~%

1,3-Diisobutyl-8-methylxanthine Structure

1,3-Diisobutyl-...

1-methyl-3-propylurea Structure

1-methyl-3-prop...

~%

3,7-Dihydro-1-methyl-3-propyl-1H-purine-2,6-dione Structure

3,7-Dihydro-1-m...

1-benzyl-3-methyl-urea Structure

1-benzyl-3-meth...

~%

3-benzyl-1-methyl-7H-purine-2,6-dione Structure

3-benzyl-1-meth...

6-AMINO-1-BENZYL-3-METHYLPYRIMIDINE-2,4(1H,3H)-DIONE Structure

6-AMINO-1-BENZY...

~%

3-benzyl-1-methyl-7H-purine-2,6-dione Structure

3-benzyl-1-meth...

6-amino-1-benzyl-3-methyl-5-nitroso uracil Structure

6-amino-1-benzy...

~%

3-benzyl-1-methyl-7H-purine-2,6-dione Structure

3-benzyl-1-meth...

Formic Acid Structure

N/A Structure

~%

3-benzyl-1-methyl-7H-purine-2,6-dione Structure

3-benzyl-1-meth...

1,3-diisobutyl-4-aminouracil Structure

1,3-diisobutyl-...

~%

1,3-bis(2-methylpropyl)-7H-purine-2,6-dione Structure

1,3-bis(2-methy...

1,3-bis(2-methylpropyl)urea Structure

1,3-bis(2-methy...

~%

1,3-bis(2-methylpropyl)-7H-purine-2,6-dione Structure

1,3-bis(2-methy...

1,3-diisobutyl-4-amino-5-nitrosouracil Structure

1,3-diisobutyl-...

~%

1,3-bis(2-methylpropyl)-7H-purine-2,6-dione Structure

1,3-bis(2-methy...

Isobutylamine Structure

Ethyl carbonate Structure

Ethyl carbonate

~93%

1,3-bis(2-methylpropyl)urea Structure

1,3-bis(2-methy...

6-AMINO-1-BUTYL-3-METHYL-1H-PYRIMIDINE-2,4-DIONE Structure

6-AMINO-1-BUTYL...

~%

1-methyl-3-butylxanthine Structure

1-methyl-3-buty...

Urea,N-butyl-N'-methyl- Structure

Urea,N-butyl-N'...

~%

1-methyl-3-butylxanthine Structure

1-methyl-3-buty...

6-amino-1-butyl-3-methyl-5-nitrosopyrimidine-2,4(1H,3H)-dione Structure

6-amino-1-butyl...

~%

1-methyl-3-butylxanthine Structure

1-methyl-3-buty...

Formic Acid Structure

5,6-diamino-1-butyl-3-methylpyrimidine-2,4-dione Structure

5,6-diamino-1-b...

~%

1-methyl-3-butylxanthine Structure

1-methyl-3-buty...