Tetrahedron letters

A novel preparation of methyl ketones through one-carbon homologation of aldehydes

L Wang, P Li, J Yan, Z Wu

Index: Wang, Lei; Li, Pinhua; Yan, Jincan; Wu, Zhongzhi Tetrahedron Letters, 2003 , vol. 44, # 25 p. 4685 - 4688

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Citation Number: 5

Abstract

Conversion of aldehydes to the homologous methyl ketones is an important functional group transformation in organic synthesis and a variety of methods have been recommended for this purpose. The traditional synthetic method involves a Grignard or organolithium reagent addition to an aldehyde followed by oxidation of alcohol. 1., , , , and On the other hand, the direct insertion of an alkylidene unit from diazomethane to the aldehyde CH bonds is also an effective ...