Brønsted acid-catalyzed efficient Strecker reaction of ketones, amines and trimethylsilyl cyanide

GW Zhang, DH Zheng, J Nie, T Wang…

Index: Zhang, Guang-Wu; Zheng, Dong-Hua; Nie, Jing; Wang, Teng; Ma, Jun-An Organic and Biomolecular Chemistry, 2010 , vol. 8, # 6 p. 1399 - 1405

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Citation Number: 50

Abstract

A general method for the one-pot, three-component Strecker reaction of ketones was developed using Brønsted acids as organocatalysts. A series of α-aminonitriles were obtained in good to excellent yields (79–99%). A preliminary extension to a catalytic enantioselective three-component Strecker reaction of ketones (up to 40% ee) is also described.

~10%

~97%

~99%

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