Design and synthesis of 2-cyano-3, 12-dioxoolean-1, 9-dien-28-oic acid, a novel and highly active inhibitor of nitric oxide production in mouse macrophages

T Honda, BAV Rounds, GW Gribble, N Suh…

Index: Bioorganic and Medicinal Chemistry Letters, , vol. 8, # 19 p. 2711 - 2714

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Citation Number: 185

Abstract

... Bioorganic & Medicinal Chemistry Letters. ... b Department of Pharmacology and Toxicology, Dartmouth Medical School, Hanover, NH 03755, USA. Received 2 July 1998, Accepted 11 August 1998, Available online 2 December 1998. Abstract. ...

 Related Synthetic Route
methyl (4aS,6aR,6bS,8aR,12aS,14aR,14bS)-11-formyl-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-1,3,4,5,6,6a,6b,7,8,8a,9,10,11,12,12a,14,14a,14b-octadecahydropicene-4a(2H)-carboxylate Structure

218600-51-2

methyl (4aS,6aR...

~%

Bardoxolone Methyl Structure

218600-53-4

Bardoxolone Methyl

methyl (4aS,6aR,6bS,8aR,12aS,14aR,14bS)-11-formyl-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-1,3,4,5,6,6a,6b,7,8,8a,9,10,11,12,12a,14,14a,14b-octadecahydropicene-4a(2H)-carboxylate Structure

218600-51-2

methyl (4aS,6aR...

~%

Bardoxolone Structure

218600-44-3

Bardoxolone


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