Synthetic oleanane and ursane triterpenoids with modified rings A and C: a series of highly active inhibitors of nitric oxide production in mouse macrophages

T Honda, BAV Rounds, L Bore, HJ Finlay…

Index: Honda; Rounds; Bore; Finlay; Favaloro Jr.; Suh; Wang; Sporn; Gribble Journal of Medicinal Chemistry, 2000 , vol. 43, # 22 p. 4233 - 4246

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Citation Number: 226

Abstract

We have designed and synthesized 16 new olean-and urs-1-en-3-one triterpenoids with various modified rings C as potential antiinflammatory and cancer chemopreventive agents and evaluated their inhibitory activities against production of nitric oxide induced by interferon-γ in mouse macrophages. This investigation revealed that 9 (11)-en-12-one and 12-en-11-one functionalities in ring C increase the potency by about 2-10 times compared ...