Tetrahedron

Kröhnke reaction in aqueous media: one-pot clean synthesis of 4′-aryl-2, 2′: 6′, 2 ″-terpyridines

S Tu, R Jia, B Jiang, J Zhang, Y Zhang, C Yao, S Ji

Index: Tu, Shujiang; Jia, Runhong; Jiang, Bo; Zhang, Junyong; Zhang, Yan; Yao, Changsheng; Ji, Shunjun Tetrahedron, 2007 , vol. 63, # 2 p. 381 - 388

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Citation Number: 98

Abstract

A clean aqueous Kröhnke reaction process has been accomplished via a one-pot procedure of 2-acetylpyridine with aromatic aldehyde and ammonium acetate under microwave irradiation or conventional heating conditions. This method is convenient, economic and environmental friendly.

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