Organic letters

Synthesis of Multisubstituted Pyridines

Z He, D Dobrovolsky, P Trinchera, AK Yudin

Index: He, Zhi; Dobrovolsky, Dennis; Trinchera, Piera; Yudin, Andrei K. Organic Letters, 2013 , vol. 15, # 2 p. 334 - 337

Full Text: HTML

Citation Number: 22

Abstract

By utilizing amino allenes, aldehydes, and aryl iodides as readily available building blocks, a simple and modular synthesis of multisubstituted pyridines with flexible control over the substitution pattern has been achieved. The method employs a two-step procedure involving the preparation of “skipped” allenyl imines and a subsequent palladium-catalyzed cyclization.