The Journal of Organic Chemistry

Pteridines. XXXII. 2-Amino-3-cyano-5-chloromethylpyrazine 1-oxide and its conversion to 6-alkenyl-substituted pteridines

EC Taylor, T Kobayashi

Index: Taylor,E.C.; Kobayashi,T. Journal of Organic Chemistry, 1973 , vol. 38, p. 2817 - 2821

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Citation Number: 29

Abstract

2-Amino-3-cyano-5-ohloromethylpyrazine 1-oxide (2), prepared by the condensation of p- chloropyruvaldoxime with aminomalononitrile tosylate, was deoxygenated with phosphorus trichloride to 2-amino-3-cyano-5-chloromethylpyrazine (4). Both 2 and 4 were converted by conventional procedures to triphenylphosphonium ylides (Wittig reagents) and, hence, by condensation with aldehydes to parallel series of 5-alkenylpyrazines (9 and 10). ...