Tetrahedron

A novel and efficient solvent-free and heterogeneous method for the synthesis of primary, secondary and bis-N-acylsulfonamides using metal hydrogen sulfate …

…, M Hoseinpour, A Molseghi, RJ Kalbasi, HJ Naghash

Index: Massah, Ahmad Reza; Asadi, Beheshteh; Hoseinpour, Mahdieh; Molseghi, Azadeh; Kalbasi, Roozbeh Javad; Javaherian Naghash, Hamid Tetrahedron, 2009 , vol. 65, # 36 p. 7696 - 7705

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Citation Number: 19

Abstract

Some metal hydrogen sulfates were used as acid catalysts in the N-acylation of different sulfonamides using carboxylic acid chlorides and anhydrides as acylating agents under both heterogeneous and solvent-free conditions. Al (HSO4) 3 and Zr (HSO4) 4 were found to have the highest activity and catalyze the reactions efficiently to furnish the primary N-acyl sulfonamides (RCONHSO2R′), secondary N-acylsulfonamides (RCONR ″SO2R′) and ...