Syntheses and evaluation of anticonvulsant profile and teratogenicity of novel amide derivatives of branched aliphatic carboxylic acids with 4- …

…, B Wlodarczyk, RH Finnell, B Yagen

Index: Hen, Naama; Bialer, Meir; Wlodarczyk, Bogdan; Finnell, Richard H.; Yagen, Boris Journal of Medicinal Chemistry, 2010 , vol. 53, # 10 p. 4177 - 4186

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Citation Number: 20

Abstract

Despite the availability of 14 new antiepileptic drugs (AEDs), about 30% of epileptic patients are not seizure-free. Consequently there is substantial need to develop new effective AEDs. A novel class of aromatic amides composed of phenylacetic acid or branched aliphatic carboxylic acids, with five to nine carbons in their carboxylic moiety, and aminobenzenesulfonamide were synthesized and evaluated in the anticonvulsant rat- ...