Complementary lipase-mediated desymmetrization processes of 3-aryl-1, 5-disubstituted fragments. Enantiopure synthetic valuable carboxylic acid derivatives

…, V Gotor-Fernández, V Gotor

Index: Rios-Lombardia, Nicolas; Gotor-Fernandez, Vicente; Gotor, Vicente Journal of Organic Chemistry, 2011 , vol. 76, # 3 p. 811 - 819

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Citation Number: 16

Abstract

Desymmetrizaton enzymatic processes have been extensively studied searching for optimal methods of producing enantioenriched monoacetates from prochiral diols and diesters. AK lipase has been found as an excellent biocatalyst for the desymmetriaztion of a series of previously synthesized 3-arylpentane-1, 5-diols derivatives. The access to (S)-or (R)- monoacetates in high optical purity (86− 99% ee) has been possible by using acetylation ...