Complementary lipase-mediated desymmetrization processes of 3-aryl-1, 5-disubstituted fragments. Enantiopure synthetic valuable carboxylic acid derivatives

…, V Gotor-Fernández, V Gotor

文献索引：Rios-Lombardia, Nicolas; Gotor-Fernandez, Vicente; Gotor, Vicente Journal of Organic Chemistry, 2011 , vol. 76, # 3 p. 811 - 819

全文：HTML全文

被引用次数: 16

摘要

Desymmetrizaton enzymatic processes have been extensively studied searching for optimal methods of producing enantioenriched monoacetates from prochiral diols and diesters. AK lipase has been found as an excellent biocatalyst for the desymmetriaztion of a series of previously synthesized 3-arylpentane-1, 5-diols derivatives. The access to (S)-or (R)- monoacetates in high optical purity (86− 99% ee) has been possible by using acetylation ...