Identification of a potent and noncytotoxic inhibitor of melanin production

…, SK Ha, E Lee, TY Kim, SY Kim, S Choi, S Kim

Index: Hwang, Soonho; Choi, Sang Yoon; Lee, Jin Hee; Kim, Shinae; In, Jinkyung; Ha, Sang Keun; Lee, Eunjung; Kim, Tae-Yoon; Kim, Sun Yeou; Choi, Sun; Kim, Sanghee Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 15 p. 5602 - 5609

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Citation Number: 14

Abstract

On the basis of a hit from random screening, biaryl amide derivatives were prepared in a combinatorial manner via parallel solution-phase synthesis, and their effects on melanocytes were investigated to discover new effective skin depigmenting agents. Among the 120 derivatives prepared, five members exhibited a> 30% reduction of melanin production at 30μM with a cell viability of> 90%. In particular, compound A3/B5 exhibited ...