European journal of medicinal chemistry

Acyl hydrazides and triazoles as novel inhibitors of mammalian cathepsin B and cathepsin H

N Raghav, M Singh

Index: Raghav, Neera; Singh, Mamta European Journal of Medicinal Chemistry, 2014 , vol. 77, p. 231 - 242

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Citation Number: 12

Abstract

Abstract In the past decade, the work on the identification of small molecular weight compounds as inhibitors of cysteine proteases has been in focus. In this direction, we here present the facile microwave assisted synthesis of some acyl hydrazides and triazoles, followed by their evaluation as protease inhibitors and inhibitory studies on cathepsin B and cathepsin H, two significant lysosomal cysteine proteases. The compounds were ...