Design, synthesis and SAR study of hydroxychalcone inhibitors of human β-secretase (BACE1)

L Ma, Z Yang, C Li, Z Zhu, X Shen…

Index: Journal of Enzyme Inhibition and Medicinal Chemistry, , vol. 26, # 5 p. 643 - 648

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Citation Number: 9

Abstract

... Journal of Enzyme Inhibition and Medicinal Chemistry. ... describe the development of low molecular weight BACE1 inhibitors containing a chalcone skeleton through enzymatic assays ... the assay was carried out by incubation of the substrate peptide (5 µM), BACE1 enzyme (550 ng ...

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Design, synthesis and SAR study of hydroxychalcone inhibitor...

[Ma, Lei; Yang, Zhengyi; Li, Chenjing; Zhu, Zhiyuan; Shen, Xu; Hu, Lihong Journal of Enzyme Inhibition and Medicinal Chemistry, 2011 , vol. 26, # 5 p. 643 - 648]

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