2-Hydroxychalcone

Modify Date: 2024-01-11 18:42:12

2-Hydroxychalcone structure	Common Name	2-Hydroxychalcone
	CAS Number	644-78-0	Molecular Weight	224.25500
	Density	1.191g/cm3	Boiling Point	396.566ºC at 760 mmHg
	Molecular Formula	C₁₅H₁₂O₂	Melting Point	144-150ºC(lit.)
	MSDS	N/A	Flash Point	169.35ºC

Use of 2-Hydroxychalcone

2-hydroxychalcone, a natural flavonoid, is a potent antioxidant, inhibiting lipid peroxidation. 2-Hydroxychalcone induces apoptosis by Bcl-2 downregulation. 2-Hydroxychalcone inhibits the activation of NF-kB[1][2][3].

Name	2-Hydroxychalcone
Synonym	More Synonyms

Description	2-hydroxychalcone, a natural flavonoid, is a potent antioxidant, inhibiting lipid peroxidation. 2-Hydroxychalcone induces apoptosis by Bcl-2 downregulation. 2-Hydroxychalcone inhibits the activation of NF-kB[1][2][3].
Related Catalog	Signaling Pathways >> Apoptosis >> Bcl-2 Family Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Research Areas >> Metabolic Disease
In Vitro	2-Hydroxychalcone inhibits invasion of triple negative breast cancer cells[1]. 2-hydroxychalcone inhibits the adhesion of peripheral neutrophils to the endothelial cell monolayers by inhibiting the expression of ICAM-1, VCAM-1, and E-selectin in a concentration-dependent manner[2].
References	[1]. Sun Young Kim, et al. 2-Hydroxychalcone and Xanthohumol Inhibit Invasion of Triple Negative Breast Cancer Cells. Chem Biol Interact. 2013 May 25;203(3):565-72. [2]. B Madan, et al. 2'-hydroxychalcone Inhibits Nuclear factor-kappaB and Blocks Tumor Necrosis Factor-Alpha- And Lipopolysaccharide-Induced Adhesion of Neutrophils to Human Umbilical Vein Endothelial Cells. Mol Pharmacol. 2000 Sep;58(3):526-34. [3]. BABITA MADAN, et al. 2-Hydroxychalcone Inhibits Nuclear Factor-kB and Blocks Tumor Necrosis Factor-a- and Lipopolysaccharide-Induced Adhesion of Neutrophils to Human Umbilical Vein Endothelial Cells. Mol Pharmacol 58:526–534, 2000.

Density	1.191g/cm3
Boiling Point	396.566ºC at 760 mmHg
Melting Point	144-150ºC(lit.)
Molecular Formula	C₁₅H₁₂O₂
Molecular Weight	224.25500
Flash Point	169.35ºC
Exact Mass	224.08400
PSA	37.30000
LogP	3.28830
Index of Refraction	1.654

2-Hydroxychalcone MSDS(Chinese)

Hazard Codes	Xi
Risk Phrases	R36/37/38
Safety Phrases	S26-S36
WGK Germany	3
HS Code	2914501900

Precursor 9
CAS#:90-02-8 Salicylaldehyde CAS#:98-86-2 Acetophenone CAS#:89-95-2 2-Methylbenzyl ... CAS#:13636-88-9 2-Propen-1-one,...
CAS#:31487-82-8 1-[2-(BENZYLOXY... CAS#:100-52-7 Benzaldehyde CAS#:582-24-1 Glycolophenone CAS#:5896-17-3 2-(Benzyloxy)be...
CAS#:6272-41-9 2-Phenylbenzopy...
DownStream 10
CAS#:3516-95-8 2'-Hydroxy-3-ph... CAS#:487-26-3 FLAVANONE CAS#:1621-55-2 3-Hydroxy-2-phe... CAS#:18732-50-8 6-(5-phenyl-1,2...
CAS#:70460-60-5 2-Phenyl-2H-chr... CAS#:75630-71-6 (5,7-DIBROMO-1-... CAS#:67139-38-2 6-(3-phenyl-2H-... CAS#:89406-21-3 2-(4-phenyl-2,3...
CAS#:4376-83-4 3-(2-Hydroxyphe... CAS#:6274-71-1 2,4-diphenylchr...

HS Code	2914501900
Summary	2914501900 other ketone-phenols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

3-(2-hydroxyphenyl)-1-phenylprop-2-en-1-one

EINECS 211-422-1

MFCD00016449

2-Hydroxychalcone

Use of 2-Hydroxychalcone

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2-Hydroxychalcone Biological Activity

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