米罗那非

• 常用名: 米罗那非
• 英文名: Mirodenafil
• CAS号: 862189-95-5
• 分子量: 531.667
• 密度: 1.3±0.1 g/cm3
• 沸点: 730.4±70.0 °C at 760 mmHg
• 分子式: C₂₆H₃₇N₅O₅S
• 熔点: N/A
• 闪点: 395.6±35.7 °C

米罗那非用途

Mirodenafil(SK3530)是磷酸二酯酶5(PDE-5)抑制剂,可作用于勃起功能紊乱。

米罗那非名称

• 中文名: 米罗那非
• 英文名: 5-ethyl-2-[5-[4-(2-hydroxyethyl)piperazin-1-yl]sulfonyl-2-propoxyphenyl]-7-propyl-1H-pyrrolo[3,2-d]pyrimidin-4-one

米罗那非生物活性

• 描述: Mirodenafil(SK3530)是磷酸二酯酶5(PDE-5)抑制剂,可作用于勃起功能紊乱。
• 相关类别:
  信号通路 >> 代谢酶/蛋白酶 >> 磷酸二酯酶(PDE)
  研究领域 >> 其他
• 参考文献:

  [1]. Paick, J.S., et al., Efficacy and safety of mirodenafil, a new oral phosphodiesterase type 5 inhibitor, for treatment of erectile dysfunction. J Sex Med, 2008. 5(11): p. 2672-80.

  [2]. Kim, B.H., et al., Influence of alcohol on the hemodynamic effects and pharmacokinetic properties of mirodenafil: a single-dose, randomized-sequence, open-label, crossover study in healthy male volunteers in Korea. Clin Ther, 2009. 31(6): p. 1234-43.

  [3]. Shin, K.H., et al., The effects of ketoconazole and rifampicin on the pharmacokinetics of mirodenafil in healthy Korean male volunteers: an open-label, one-sequence, three-period, three-treatment crossover study. Clin Ther, 2009. 31(12): p. 3009-20.

米罗那非物理化学性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 730.4±70.0 °C at 760 mmHg
• 分子式: C₂₆H₃₇N₅O₅S
• 分子量: 531.667
• 闪点: 395.6±35.7 °C
• 精确质量: 531.251526
• PSA: 129.14000
• LogP: 4.11
• 蒸汽压: 0.0±2.5 mmHg at 25°C
• 折射率: 1.637
• 储存条件: 2-8℃

米罗那非英文别名

• 5-Ethyl-2-(5-{[4-(2-hydroxyethyl)-1-piperazinyl]sulfonyl}-2-propoxyphenyl)-7-propyl-1,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
• Mirodenafil
• 4H-Pyrrolo[3,2-d]pyrimidin-4-one, 5-ethyl-1,5-dihydro-2-[5-[[4-(2-hydroxyethyl)-1-piperazinyl]sulfonyl]-2-propoxyphenyl]-7-propyl-
• UNII-504G362H0H