甲基丙烯酸甲酯

常用名 甲基丙烯酸甲酯 英文名 methyl methacrylate
CAS号 80-62-6 分子量 100.116
密度 0.9±0.1 g/cm3 沸点 100.3±0.0 °C at 760 mmHg
分子式 C5H8O2 熔点 -48ºC
MSDS甲基丙烯酸甲酯的MSDS|SDS|pdf下载 中文版 美版 闪点 10.0±0.0 °C
符号 GHS02 GHS06 GHS08
GHS02, GHS06, GHS08
信号词 Danger

 甲基丙烯酸甲酯用途


1.用于制造有机玻璃、涂料、润滑油添加剂、木材浸润剂、纸张上光剂等。

2.甲基丙烯酸甲酯既是一种有机化工原料,又可作为一种化工产品直接应用。作为有机化工原料,主要应用于有机玻璃(聚甲基丙烯酸甲酯,PM-MA)的生产,也用于聚氯乙烯助剂ACR的制造以及作为第二单体应用于腈纶生产。此外,在胶黏剂、涂料、树脂、纺织、造纸等行业也得到了广泛的应用。作为一种化工产品,可直接应用于皮革、离子交换树脂、纸张上光剂、纺织印染助剂、皮革处理剂、润滑油添加剂、原油降凝剂、木材和软木材的浸润剂、电机线圈的浸透剂、绝缘灌注材料和塑料型乳液的增塑剂、地板抛光、不饱和树脂改性、甲基丙烯酸高级酯类等许多领域。

3.有机合成单体。也用于制造其他树脂、塑料、涂料、胶黏剂、阻垢分散剂、润滑剂、木材浸润剂、电机线圈浸透剂、纸张上光剂、印染助剂和绝缘灌注材料。

4.用作有机玻璃的单体,也用于制造其他树脂、塑料、涂料、黏合剂、润滑剂、木材和软木的浸润剂、纸张上光剂等。

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 甲基丙烯酸甲酯名称

[ 中文名 ]: 甲基丙烯酸甲酯
[ 英文名 ]: methyl methacrylate
[中文别名 ]: 异丁烯酸甲酯
甲基败脂酸甲酯,2-甲基-2-丙烯酸甲酯,异丁烯酸甲酯
2-甲基-2-丙烯酸甲酯
甲基丙烯酸甲酯
[英文别名 ]: EINECS 201-297-1
2-Propenoicacid, 2-methyl-, methyl ester
Methyl methacrylate
MFCD00008587

 甲基丙烯酸甲酯物理化学性质

[ 密度 ]: 0.9±0.1 g/cm3
[ 沸点 ]: 100.3±0.0 °C at 760 mmHg
[ 熔点 ]: -48ºC
[ 分子式 ]: C5H8O2
[ 分子量 ]: 100.116
[ 闪点 ]: 10.0±0.0 °C
[ 精确质量 ]: 100.052429
[ PSA ]: 26.30000
[ LogP ]: 1.35
[ 外观性状 ]: 无色液体
[ 蒸汽压 ]: 36.9±0.1 mmHg at 25°C
[ 折射率 ]: 1.400
[ 储存条件 ]:

储存注意事项通常商品加有阻聚剂。储存于阴凉、通风的库房。远离火种、热源。避光保存。库温不宜超过37℃。包装要求密封,不可与空气接触。应与氧化剂、酸类、碱类、卤素等分开存放,切忌混储。不宜大量储存或久存。采用防爆型照明、通风设施。禁止使用易产生火花的机械设备和工具。储区应备有泄漏应急处理设备和合适的收容材料。

[ 稳定性 ]:

1.易挥发,易燃,与空气形成爆炸性混合物,溶于乙醇、乙醚、丙酮等多种有机溶剂,微溶于乙二醇和水。受光、热和催化作用易聚合,也可与其他单体共聚,由于存在双键和羧酸基团,还易进行加成、卤化、亲核取代核酯交换反应。易聚合。通常加入10-5氢醌单甲醚作阻聚剂。

2.本品毒性较小。大鼠经口LD50为9400mg/kg。吸入致死浓度Lc5015.33g/m3,作业最高容许浓度为410mg/m3。但其嗅阈为130~250mg/m3,当其浓度尚未达产生毒性之前,其强烈臭味已使人难忍。人体皮肤接触甲基丙烯酸甲酯,只有极少数人会出现红疹。

3.由于生产甲基丙烯酸甲酯的原料氰化钠和中间体氰化氢剧毒,生产装置必须严格保证设备密闭,并保持良好通风,操作人员应有严格的防护措施,配备必要的防护装具。发现中毒现象应立即移至空气新鲜处及时抢救。

4.稳定性 稳定

5.禁配物氧化剂、酸类、碱类、还原剂、过氧化物、胺类、卤素

6.避免接触的条件受热、光照、紫外线、接触空气

7.聚合危害 聚合

[ 分子结构 ]:

1、摩尔折射率:26.55

2、摩尔体积(cm3/mol):109.4

3、等张比容(90.2K):240.9

4、表面张力(dyne/cm):23.5

5、极化率(10-24cm3):10.52

[ 计算化学 ]:

1.疏水参数计算参考值(XlogP):无

2.氢键供体数量:0

3.氢键受体数量:2

4.可旋转化学键数量:2

5.互变异构体数量:无

6.拓扑分子极性表面积26.3

7.重原子数量:7

8.表面电荷:0

9.复杂度:94.3

10.同位素原子数量:0

11.确定原子立构中心数量:0

12.不确定原子立构中心数量:0

13.确定化学键立构中心数量:0

14.不确定化学键立构中心数量:0

15.共价键单元数量:1

[ 更多 ]:

1.性状:无色易挥发液体,并具有强辣味。

2.熔点(℃):-48

3.沸点(℃):100.5

4.相对密度(水=1):0.94(20℃)

5.相对蒸气密度(空气=1):3.45

6.饱和蒸气压(kPa):3.9(20℃)

7.燃烧热(kJ/mol):-2642.9

8.临界温度(℃):294

9.临界压力(MPa):3.3

10.辛醇/水分配系数:1.38

11.闪点(℃):10(OC);12.8(OC)

12.引燃温度(℃):421~435

13.爆炸上限(%):12.5

14.爆炸下限(%):2.1

15.溶解性:微溶于水,溶于乙醇等多数有机溶剂。

16.黏度(mPa·s,25ºC):0.58

17.常温折射率(n20):1.4142

18.气相标准燃烧热(焓)(kJ·mol-1):-2779.8

19.气相标准声称热(焓)( kJ·mol-1) :-331.0

 甲基丙烯酸甲酯MSDS

国标编号: 32149
CAS: 80-62-6
中文名称: 甲基丙烯酸甲酯
英文名称: Methyl methacrylate;Methacrylic acid,methyl ester
别 名: 异丁烯酸甲酯;牙托水;有机玻璃单体
分子式: C5H8O2;CH2C(CH3)COOCH3
分子量: 100.12
熔 点: -50℃ 沸点:101℃
密 度: 相对密度(水=1);相对
蒸汽压: 10℃
溶解性: 微溶于水,溶于乙醇等
稳定性: 稳定
外观与性状: 无色易挥发液体,并具有强辣味
危险标记: 7(易燃液体)
用 途: 用作有机玻璃的单体,也用于制造其它树脂、塑料、涂料、粘合剂、润滑剂

2.对环境的影响:
一、健康危害
侵入途径:吸入、食入。
健康危害:人对本品气味感觉阈浓度为85mg/m 3 ,刺激作用阈浓度(暴露1分钟)为285mg/m 3。中毒表现为乏力、恶心、反复呕吐、头痛、头晕、胸闷、伴有短暂的意识消失、中性白细胞增多症。慢性中毒:神经系统受损的综合症状占主要地位,个别可发生中毒性脑病。可引起轻度皮炎和结膜炎。接触时间长可致麻醉作用。
二、毒理学资料及环境行为
毒性:为麻醉剂,麻醉浓度和致死浓度几乎相同,有弱的刺激作用。
急性毒性:LD 507872mg/kg(大鼠经口);LC 503750ppm(大鼠吸入);人吸入725ppm,最小致死浓度;人吸入62ppm×20~90分钟,粘膜刺激;人吸入12.5~25ppm×20~90分钟,头晕,恶心,意识障碍。
亚急性和慢性毒性:狗吸入46800ppm×1.5小时/日×8日,绝对致死浓度,肝、肾有损害。
致突变性:微粒体致突变:鼠伤寒沙门氏菌34mmol/L。
生殖毒性:大鼠吸入最低中毒浓度(TCL 0):109g/kg(孕6~15天用药),致胚胎毒性,对肌肉骨骼系统有影响。
危险特性:遇明火、高热或与氧化剂接触,有引起燃烧爆炸的危险。若遇高热,可能发生聚合反应,出现大量放热现象,引起容器破裂和爆炸事故。其蒸气比空气重,能在较低处扩散到相当远的地方,遇明火会引着回燃。
燃烧(分解)产物:一氧化碳、二氧化碳。

3.现场应急监测方法:


 

4.实验室监测方法:


气相色谱法《空气中有害物质的测定方法》,杭士平主编
羟胺-氯化铁比色法《空气中有害物质的测定方法》,杭士平主编

5.环境标准:

前苏联 车间空气中有害物质的最高容许浓度 10 mg/m3
前苏联(1975) 居民区大气中有害物最大允许浓度 0.1mg/m3(最大值,昼夜均值)
前苏联(1975) 水体中有害有机物的最大允许浓度 0.01mg/L
  嗅觉阈浓度 0.21ppm

6.应急处理处置方法:


一、泄漏应急处理
切断火源。戴自给式呼吸器,穿一般消防防护服。在确保安全情况下堵漏。喷水雾可减少蒸发。用砂土、蛭石或其它惰性材料吸收,然后运至空旷的地方掩埋、蒸发、或焚烧。或用不燃性分散剂制成的乳液刷洗,经稀释的洗液放入废水系统。如大量泄漏,利用围堤收容,然后收集、转移、回收或无害处理后废弃。
二、防护措施
呼吸系统防护:空气中浓度较高时,建议佩戴防毒面具。
眼睛防护:戴化学安全防护眼镜。
防护服:穿防静电工作服。
手防护:必要时戴防护手套。
其它:工作现场严禁吸烟。工作后,淋浴更衣。注意个人清洁卫生。
三、急救措施
皮肤接触:脱去污染的衣着,用肥皂水及清水彻底冲洗。
眼睛接触:立即翻开上下眼睑,用流动清水冲洗15分钟。就医。
吸入:脱离现场至空气新鲜处。呼吸困难时给输氧。呼吸停止时,立即进行人工呼吸。
食入:误服者给饮足量温水,催吐,就医。

灭火方法:雾状水、泡沫、二氧化碳、干粉、砂土。

 甲基丙烯酸甲酯毒性和生态

甲基丙烯酸甲酯毒理学数据:

1.急性毒性

LD50:7872mg/kg(大鼠经口);

LC50:78000mg/m3(大鼠吸入,4h)

2.刺激性 暂无资料

3.亚急性与慢性毒性 狗吸入11700ppm,每天1.5h,共8天,可引起动物死亡,尸检可见肝、肾脂肪变性。

4.致突变性 细胞遗传学分析:小鼠淋巴细胞2202mg/L。

5.致畸性 大鼠孕后6~15d吸入最低中毒剂量(TCLo)109g/m3(17min),致肌肉骨骼系统发育畸形。

6.其他 大鼠吸入最低中毒浓度(TCLo):109g/kg(孕6~15d用药),致胚胎毒性,对肌肉骨骼系统有影响。

甲基丙烯酸甲酯生态学数据: 1.生态毒性 TLm:499~159mg/L(24~96h)(黑头呆鱼);368~232mg/L(24~96h)(蓝鳃太阳鱼);423~277mg/L(24~96h)(金鱼)

2.生物降解性 MITI-I测试,初始浓度100ppm,污泥浓度30ppm,2周后降解94%。

3.非生物降解性 空气中,当羟基自由基浓度为5.00×105个/cm3时,降解半衰期为7.4h(理论)。

当pH值为7,8,9,11时,水解半衰期分别为4a,140d,14d,3.4h(理论)

CHEMICAL IDENTIFICATION

RTECS NUMBER :
OZ5075000
CHEMICAL NAME :
Methacrylic acid, methyl ester
CAS REGISTRY NUMBER :
80-62-6
BEILSTEIN REFERENCE NO. :
0605459
LAST UPDATED :
199803
DATA ITEMS CITED :
102
MOLECULAR FORMULA :
C5-H8-O2
MOLECULAR WEIGHT :
100.13
WISWESSER LINE NOTATION :
1UY1&VO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Open irritation test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Human
DOSE/DURATION :
125 ppm
TOXIC EFFECTS :
Behavioral - sleep Behavioral - excitement Behavioral - anorexia (human)
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Human
DOSE/DURATION :
60 mg/m3
TOXIC EFFECTS :
Behavioral - sleep Behavioral - excitement Vascular - BP lowering not characterized in autonomic section
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
7872 mg/kg
TOXIC EFFECTS :
Behavioral - muscle weakness Behavioral - coma Lungs, Thorax, or Respiration - respiratory depression
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
78000 mg/m3/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1328 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
7088 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
3625 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
18500 mg/m3/2H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
945 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
5954 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
4725 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - ataxia Gastrointestinal - changes in structure or function of salivary glands
TYPE OF TEST :
LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
41200 mg/m3/3H
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - ataxia Gastrointestinal - changes in structure or function of salivary glands
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
4252 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
120 uL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Mammal - cat
DOSE/DURATION :
7 mL/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Kidney, Ureter, Bladder - changes primarily in glomeruli Biochemical - Metabolism (Intermediary) - porphyrin including bile pigments
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
8700 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
17500 mg/m3/4.5H
TOXIC EFFECTS :
Behavioral - muscle weakness Behavioral - coma Lungs, Thorax, or Respiration - respiratory depression
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
>5 gm/kg
TOXIC EFFECTS :
Skin and Appendages - dermatitis, other (after systemic exposure)
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
14 mL/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - other changes Kidney, Ureter, Bladder - hematuria
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
5954 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - ataxia Gastrointestinal - changes in structure or function of salivary glands
TYPE OF TEST :
LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
19000 mg/m3/5H
TOXIC EFFECTS :
Behavioral - muscle weakness Behavioral - coma Lungs, Thorax, or Respiration - respiratory depression
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
1890 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
5954 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Mammal - species unspecified
DOSE/DURATION :
20 gm/m3
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
10500 mg/kg/21D-I
TOXIC EFFECTS :
Peripheral Nerve and Sensation - structural change in nerve or sheath Behavioral - somnolence (general depressed activity) Biochemical - Metabolism (Intermediary) - lipids including transport
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
17896 mg/kg/35W-I
TOXIC EFFECTS :
Gastrointestinal - ulceration or bleeding from stomach Liver - other changes
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
116 ppm/8H/26W-I
TOXIC EFFECTS :
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Nutritional and Gross Metabolic - changes in phosphorus Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
5000 ppm/6H/14W-I
TOXIC EFFECTS :
Brain and Coverings - changes in circulation (hemorrhage, thrombosis, etc.) Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Related to Chronic Data - death
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
34500 mg/m3/16W-I
TOXIC EFFECTS :
Liver - fatty liver degeneration Kidney, Ureter, Bladder - other changes Biochemical - Metabolism (Intermediary) - amino acids (including renal excretion)
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1 mg/m3/24H/60D-C
TOXIC EFFECTS :
Behavioral - muscle contraction or spasticity Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase Biochemical - Metabolism (Intermediary) - porphyrin including bile pigments
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
115 mg/m3/3H/17W-I
TOXIC EFFECTS :
Cardiac - EKG changes not diagnostic of specified effects Blood - other changes
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
500 ppm/6H/2Y-I
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Lungs, Thorax, or Respiration - fibrosis, focal (pneumoconiosis)
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
41 gm/m3/90M/15D-I
TOXIC EFFECTS :
Related to Chronic Data - death
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
5000 ppm/6H/14W-I
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Liver - hepatitis (hepatocellular necrosis), zonal Related to Chronic Data - death
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
500 ppm/6H/2Y-I
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Lungs, Thorax, or Respiration - fibrosis, focal (pneumoconiosis)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
19665 mL/kg/15W-I
TOXIC EFFECTS :
Related to Chronic Data - death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
1825 mg/kg/2Y-C
TOXIC EFFECTS :
Endocrine - changes in spleen weight
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
47 gm/m3/90M/15D-I
TOXIC EFFECTS :
Liver - fatty liver degeneration Related to Chronic Data - death
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Mammal - cat
DOSE/DURATION :
15 gm/m3/7H/5D-I
TOXIC EFFECTS :
Related to Chronic Data - death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
97500 ug/kg/39W-I
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes Liver - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
15 gm/m3/7H/5D-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - other changes in urine composition Biochemical - Metabolism (Intermediary) - porphyrin including bile pigments
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
65 gm/m3/3H/3D-I
TOXIC EFFECTS :
Liver - fatty liver degeneration Related to Chronic Data - death
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - hamster
DOSE/DURATION :
400 ppm/6H/78W-I
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Implant
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1620 mg/kg
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Tumorigenic - tumors at site of application
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
DOSE :
10 mg/m3
SEX/DURATION :
female 9 year(s) after conception
TOXIC EFFECTS :
Reproductive - Maternal Effects - other effects Reproductive - Effects on Embryo or Fetus - extra-embryonic structures (e.g., placenta, umbilical cord) Reproductive - Effects on Newborn - delayed effects
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
DOSE :
109 gm/m3/17M
SEX/DURATION :
female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
DOSE :
109 gm/m3/54M
SEX/DURATION :
female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death Reproductive - Specific Developmental Abnormalities - other developmental abnormalities
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
DOSE :
54 mg/m3/24H
SEX/DURATION :
female 8 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - menstrual cycle changes or disorders
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
DOSE :
4480 mg/m3/2H
SEX/DURATION :
female 6-18 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
405 mg/kg
SEX/DURATION :
female 5-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - other developmental abnormalities
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
801 mg/kg
SEX/DURATION :
female 5-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - other developmental abnormalities
TYPE OF TEST :
Cytogenetic analysis

MUTATION DATA

TYPE OF TEST :
Sister chromatid exchange
TEST SYSTEM :
Rodent - hamster Ovary
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-314,1986 *** REVIEWS *** ACGIH TLV-Not classifiable as a human carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 410 mg/m3 (100 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 19,187,1979 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 19,187,1979 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 60,445,1994 IARC Cancer Review:Animal LACK CARCINOGENICITY IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 60,445,1994 IARC Cancer Review:Group 3 IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 60,445,1994 TOXICOLOGY REVIEW EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972- Volume(issue)/page/year: 11,141,1975 TOXICOLOGY REVIEW CMTVAS Cahiers de Medecine du Travail. (Association Professionnelle Belge des Medecine du Travail, rue du Bultia, 6280 Gerpinnes, Belgium) V.1- 1963- Volume(issue)/page/year: 10(3),49,1973 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 100 ppm (410 mg/m3) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,168,1971 OSHA PEL (Gen Indu):8H TWA 100 ppm (410 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 100 ppm (410 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 100 ppm (410 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 100 ppm (410 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 100 ppm (410 mg/m3) JAN 1993 OEL-BELGIUM:TWA 100 ppm (410 mg/m3) JAN 1993 OEL-DENMARK:TWA 75 ppm (307 mg/m3) JAN 1993 OEL-FINLAND:TWA 100 ppm (410 mg/m3);STEL 150 ppm (615 mg/m3) JAN 1993 OEL-FRANCE:TWA 100 ppm (410 mg/m3);STEL 200 ppm (820 mg/m3) JAN 1993 OEL-GERMANY:TWA 50 ppm (210 mg/m3) JAN 1993 OEL-HUNGARY:TWA 50 mg/m3;STEL 150 mg/m3 JAN 1993 OEL-THE NETHERLANDS:TWA 100 ppm (410 mg/m3) JAN 1993 OEL-THE PHILIPPINES:TWA 100 ppm (410 mg/m3) JAN 1993 OEL-POLAND:TWA 50 mg/m3 JAN 1993 OEL-RUSSIA:STEL 10 mg/m3 JAN 1993 OEL-SWEDEN:TWA 50 ppm (200 mg/m3);STEL 150 ppm (600 mg/m3);Skin JAN 1993 OEL-SWITZERLAND:TWA 50 ppm (210 mg/m3);STEL 100 ppm (420 mg/m3) JAN 1993 OEL-UNITED KINGDOM:TWA 100 ppm (410 mg/m3);STEL 125 ppm JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO METHYL METHACRYLATE-air:10H TWA 100 ppm REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 47700 No. of Facilities: 11522 (estimated) No. of Industries: 89 No. of Occupations: 73 No. of Employees: 89435 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 47700 No. of Facilities: 6757 (estimated) No. of Industries: 76 No. of Occupations: 80 No. of Employees: 170079 (estimated) No. of Female Employees: 59519 (estimated)

 甲基丙烯酸甲酯安全信息

[ 符号 ]: GHS02 GHS06 GHS08
GHS02, GHS06, GHS08
[ 信号词 ]: Danger
[ 危害声明 ]: H225-H301 + H311 + H331-H370
[ 警示性声明 ]: P210-P260-P280-P301 + P310-P311
[ 个人防护装备 ]: Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US)
[ 危害码 (欧洲) ]: F:Flammable
[ 风险声明 (欧洲) ]: R11;R37/38;R43
[ 安全声明 (欧洲) ]: S24-S37-S46
[ 危险品运输编码 ]: UN 1247
[ RTECS号 ]: OZ5075000
[ 包装等级 ]: II
[ 海关编码 ]: 3824909990

 甲基丙烯酸甲酯合成线路

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 甲基丙烯酸甲酯制备

1.丙酮氰醇法
丙酮与氰化氢反应生成丙酮氰醇,丙酮氰醇与硫酸及甲醇反应,制得甲基丙烯酸甲酯,得到的粗酯经盐析、初馏、精馏得产品。

80-62-6 preparation

2.丙烯法
丙烯、一氧化碳与甲醇反应,合成中间体2-甲氧基-2-甲基丙酸甲酯,将它分解生成甲基丙烯酸甲酯和甲醇。

80-62-6 preparation

80-62-6 preparation

3.异丁烯法
将异丁烯用氧化剂在K2CO3或MnO2催化剂存在下氧化成甲基丙烯酸或用空气在钼催化剂存在下分两段氧化,即先氧化成甲基丙烯醛,进一步氧化成甲基丙烯酸,它再与甲醇酯化制得甲基丙烯酸甲酯。

80-62-6 preparation

4.丙炔羰基化法 壳牌公司近年开发了一种丙炔羰基化合成MMA的新工艺,并已实现了工业化。据称该法比目前正在生产的或者正在开发中的任工艺都简易,且成本低。

5.乙烯法 该法是将乙烯羰基化或加氢甲酰化生成C3的羰基化合物,然后再与甲醛或与之相当的化合物缩合成甲基丙烯酸甲酯。该工艺的主要优点在于产生的氢氰酸副产物可作为制取ACH的原料循环,并且不产生硫酸铵产物。

6.制法:

80-62-6 preparation

于装有搅拌器、回流冷凝器、温度基、滴液漏斗的反应瓶中,加入磷酸三甲苯酚酯75g,五氧化二磷9g,铜粉0.2g。搅拌下油浴加热至65℃,慢慢滴加2-羟基异丁酸甲酯(2)25g(0.2mol),控制反应温度不超过65℃。加完后,升温至80~100℃,并保持此温度反应3h,改为蒸馏装置,蒸出170℃以下的馏分。馏出液用10%的碳酸钠溶液洗涤,无水磷酸钠干燥,加入少量铜粉重新蒸馏,收集97~100℃的馏分,得甲基丙烯酸甲酯(1)16~18g。收率76%~88%。注:1、加入铜粉的目的是放置甲基丙烯酸甲酯的聚合,也可加入少量的硫黄或二苯胺。2、也可由丙酮、氰化钠和甲醇为原料来合成甲基丙烯酸甲酯。

 甲基丙烯酸甲酯海关

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