1,4-双((3,5-二氯吡啶-2-基)氧基)苯

更新时间：2024-01-21 06:46:16

1,4-双((3,5-二氯吡啶-2-基)氧基)苯结构式	常用名	1,4-双((3,5-二氯吡啶-2-基)氧基)苯	英文名	TCPOBOP
	CAS号	76150-91-9	分子量	402.05900
	密度	1.518g/cm3	沸点	444.8ºC at 760 mmHg
	分子式	C₁₆H₈Cl₄N₂O₂	熔点	N/A
	MSDS	中文版美版	闪点	222.8ºC

1,4-双((3,5-二氯吡啶-2-基)氧基)苯用途

TCPOBOP 是一种组成型雄甾烷受体 (CAR) 激动剂,可诱导强健的肝细胞增殖和肝肿大,无任何肝损伤或组织缺失。TCPOBOP 通过改变 Bcl-2 蛋白减弱 Fas 诱导的小鼠肝损伤。

中文名	1,4-双((3,5-二氯吡啶-2-基)氧基)苯
英文名	3,5-dichloro-2-[4-(3,5-dichloropyridin-2-yl)oxyphenoxy]pyridine
英文别名	更多

描述	TCPOBOP 是一种组成型雄甾烷受体 (CAR) 激动剂,可诱导强健的肝细胞增殖和肝肿大,无任何肝损伤或组织缺失。TCPOBOP 通过改变 Bcl-2 蛋白减弱 Fas 诱导的小鼠肝损伤。
相关类别	信号通路 >> 细胞凋亡 >> Bcl-2家族研究领域 >> 其他
靶点	Bcl-2
体内研究	TCPOBOP(口服；3mg/kg；1-5天)在48小时时显著增加LW/BW比率中的肝脏重量与体重[1]。动物模型：MET fl/fl：靶向缺失MET KO外显子16的Tam-Cre +/+小鼠[1]剂量：3mg/kg给药：口服；1,2,5天结果：肝脏重量增加至体重。
参考文献	[1]. Bhushan B, et al. TCPOBOP-Induced Hepatomegaly and Hepatocyte Proliferation are Attenuated by Combined Disruption of MET and EGFR Signaling. Hepatology. 2019 Apr;69(4):1702-1718. [2]. Baskin-Bey ES, et al. Constitutive androstane receptor (CAR) ligand, TCPOBOP, attenuates Fas-induced murine liver injury by altering Bcl-2 proteins. Hepatology. 2006 Jul;44(1):252-62.

密度	1.518g/cm3
沸点	444.8ºC at 760 mmHg
分子式	C₁₆H₈Cl₄N₂O₂
分子量	402.05900
闪点	222.8ºC
精确质量	399.93400
PSA	44.24000
LogP	6.67480
折射率	1.635
储存条件	2-8°C，干燥，密封

1,4-双((3,5-二氯吡啶-2-基)氧基)苯毒性英文版

个人防护装备	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
危害码 (欧洲)	Xi
安全声明 (欧洲)	22-24/25
危险品运输编码	NONH for all modes of transport
WGK德国	3
RTECS号	UT7145000

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