戈那瑞林二醋酸盐结构式
|
常用名 | 戈那瑞林二醋酸盐 | 英文名 | Gonadorelin diacetate |
|---|---|---|---|---|
| CAS号 | 71447-49-9 | 分子量 | 1302.41 | |
| 密度 | N/A | 沸点 | N/A | |
| 分子式 | C55H75N17O13.2C2H4O2 | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | N/A | |
| 符号 |
GHS08 |
信号词 | Danger |
戈那瑞林二醋酸盐用途Luteinizing Hormone Releasing Hormone (LH-RH), human 是下丘脑神经肽，其在控制生殖功能中起关键作用。 |
| 中文名 | 戈那瑞林二醋酸盐 |
|---|---|
| 英文名 | Luteinizing hormone releasing hormone human acetate salt |
| 中文别名 | 戈那瑞林(GONADORELIN) | 黄体生成素释放激素 | 醋酸戈那瑞林 |
| 英文别名 | 更多 |
| 描述 | Luteinizing Hormone Releasing Hormone (LH-RH), human 是下丘脑神经肽,其在控制生殖功能中起关键作用。 |
|---|---|
| 相关类别 | |
| 体外研究 | 促黄体激素释放激素(LH-RH),也称为促性腺激素释放激素(GnRH),是大脑,垂体和性腺功能之间的主要联系,在脊椎动物繁殖中起关键作用。促黄体激素释放激素(LH-RH)及其类似物的内分泌作用是由垂体促性腺激素LHRH的高亲和力膜受体介导的[1]。 LHRH与其受体一起在激素相关的肿瘤例如前列腺癌中表达,以充当局部自分泌/旁分泌生长抑制因子。在前列腺癌细胞中,LHRH受体与Gi-cAMP途径偶联以抑制细胞增殖[3]。 |
| 体内研究 | 促黄体激素释放激素治疗使阴道开放时间延长5天,用作青春期时间的初始指标[2]。 |
| 动物实验 | 大鼠[2]未成熟雌性Sprague-Dawley大鼠在10％右旋糖，0.9％NaCl溶液中接受50ng促黄体激素释放激素（LH-RH）/ kg BW或20mg NMA / kg BW，而对照仅接受载体。完成治疗后，每天检查大鼠的阴道口[2]。 |
| 参考文献 |
| 分子式 | C55H75N17O13.2C2H4O2 |
|---|---|
| 分子量 | 1302.41 |
| PSA | 546.73000 |
| LogP | 1.28920 |
| 外观性状 | 白色或灰白色粉末 |
| 储存条件 | −20°C |
| 水溶解性 | H2O: 25 mg/mL, clear, faintly yellow |
| 符号 |
GHS08 |
|---|---|
| 信号词 | Danger |
| 危害声明 | H360 |
| 警示性声明 | P201-P308 + P313 |
| 个人防护装备 | Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges |
| 危害码 (欧洲) | T |
| 风险声明 (欧洲) | R60 |
| 安全声明 (欧洲) | 53-45 |
| 危险品运输编码 | NONH for all modes of transport |
| WGK德国 | 3 |
| RTECS号 | OK6470000 |
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Reduced melanocortin production causes sexual dysfunction in male mice with POMC neuronal insulin and leptin insensitivity.
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Developmental programming: impact of prenatal testosterone excess on pre- and postnatal gonadotropin regulation in sheep.
Biogerontology 78 , 648-60, (2008) The goal of this study was to explore mechanisms that mediate hypersecretion of LH and progressive loss of cyclicity in female sheep exposed during fetal life to excess testosterone. Our working hypot... |
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GnRH receptor and apoptotic signaling.
Vitam. Horm. 59 , 1-33, (2000) In addition to its hypophysiotropic action, gonadotropin-releasing hormone (GnRH) can modify activity in extrapituitary organs and peripheral tumors. GnRH analogs are the preferred treatment for advan... |
| UNII:7AT6GVO7OA |
| Gonadorelin acetate |
| 5-Oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosylglycyl-L-leucyl-L-arginyl-L-prolylglycinamide acetate (1:2) |
| Glycinamide, 5-oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosylglycyl-L-leucyl-L-arginyl-L-prolyl-, acetate (1:2) |
| Gonadorelin diacetate |
| Luteinizing Hormone Releasing Hormone LH-RH |
| Luteinizing Hormone Releasing Hormone (LH-RH), human |
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