PYCR1-IN-1

• 常用名: PYCR1-IN-1
• 英文名: PYCR1-IN-1
• CAS号: 709-85-3
• 分子量: 238.12
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₁H₁₂BrN
• 熔点: N/A
• 闪点: N/A

PYCR1-IN-1用途

PYCR1-IN-1 (compound 4) 是一种吡咯啉-5-羧酸还原酶 1 (PYCR1) 抑制剂,IC50 为 8.8 µM。PYCR1-IN-1 具有抗癌活性。

PYCR1-IN-1名称

• 英文名: PYCR1-IN-1

PYCR1-IN-1生物活性

• 描述: PYCR1-IN-1 (compound 4) 是一种吡咯啉-5-羧酸还原酶 1 (PYCR1) 抑制剂,IC50 为 8.8 µM。PYCR1-IN-1 具有抗癌活性。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 其他 >> 其他
• 靶点实验:

  IC50: 8.8 µM (PYCR1)[1]

• 参考文献:

  [1]. Kirsty Milne, et al. A fragment-like approach to PYCR1 inhibition. Bioorg Med Chem Lett. 2019 Sep 15;29(18):2626-2631.

PYCR1-IN-1物理化学性质

• 分子式: C₁₁H₁₂BrN
• 分子量: 238.12

PYCR1-IN-1靶点实验

查看更多实验

实验名称：Inhibition of 6x-His-tagged and SUMO tagged human PYCR1 expressed in Escherichia coli... 来源：ChEMBL 靶标：Pyrroline-5-carboxylate reductase 1, mitochondrial External Id：CHEMBL4387563

实验名称：Potency index, ratio of IC50 of pargyline to IC50 for test compound for inhibition of... 来源：ChEMBL 靶标：Pyrroline-5-carboxylate reductase 1, mitochondrial External Id：CHEMBL4387586

实验名称：Effect on valine content in human SUM159PT cells at 1 to 100 uM by LC-MS analysis rel... 来源：ChEMBL 靶标：SUM-159-PT External Id：CHEMBL4387577

实验名称：Effect on isoleucine content in human SUM159PT cells at 1 to 100 uM by LC-MS analysis... 来源：ChEMBL 靶标：SUM-159-PT External Id：CHEMBL4387578

实验名称：Inhibition of PYCR1 in human SUM159PT cells assessed as reduction proline M+5 content... 来源：ChEMBL 靶标：Pyrroline-5-carboxylate reductase 1, mitochondrial External Id：CHEMBL4387580

实验名称：Inhibition of PYCR1 in human MDA-MB-231 cells assessed as reduction in cell number at... 来源：ChEMBL 靶标：Pyrroline-5-carboxylate reductase 1, mitochondrial External Id：CHEMBL4387581

实验名称：Inhibition of PYCR1 in human SUM159PT cells assessed as reduction in cell number at 1... 来源：ChEMBL 靶标：Pyrroline-5-carboxylate reductase 1, mitochondrial External Id：CHEMBL4387582

实验名称：Inhibition of PYCR1 in human MDA-MB-231 cells assessed as reduction in cell number at... 来源：ChEMBL 靶标：Pyrroline-5-carboxylate reductase 1, mitochondrial External Id：CHEMBL4387583

实验名称：Inhibition of PYCR1 in human SUM159PT cells assessed as reduction in cell number at 1... 来源：ChEMBL 靶标：Pyrroline-5-carboxylate reductase 1, mitochondrial External Id：CHEMBL4387584

实验名称：Toxicity in human SUM159PT cells assessed as reduction in cell viability at 100 uM 来源：ChEMBL 靶标：SUM-159-PT External Id：CHEMBL4387571

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