HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Pyrroline-5-carboxylate reductase 1, mitochondrial

External ID: CHEMBL4387563

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem Lett
Year: 2019
Volume: 29
Issue: 18
First Page: 2626
Last Page: 2631
DOI: 10.1016/j.bmcl.2019.07.047

Target ChEMBL ID: CHEMBL4296002
ChEMBL Target Name: Pyrroline-5-carboxylate reductase 1, mitochondrial
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
500	IC50	>	500000	nM
38	IC50	=	38000	nM
500	IC50	>	500000	nM
500	IC50	>	500000	nM
66	IC50	=	66000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Pyrroline-5-carboxylate reductase 1, mitochondrial

External ID: CHEMBL4387586

Protocol: N/A

Comment: Journal: Bioorg Med Chem Lett
Year: 2019
Volume: 29
Issue: 18
First Page: 2626
Last Page: 2631
DOI: 10.1016/j.bmcl.2019.07.047

Target ChEMBL ID: CHEMBL4296002
ChEMBL Target Name: Pyrroline-5-carboxylate reductase 1, mitochondrial
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value
Ratio IC50	=	20

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：SUM-159-PT

External ID: CHEMBL4387577

Protocol: N/A

Comment: Journal: Bioorg Med Chem Lett
Year: 2019
Volume: 29
Issue: 18
First Page: 2626
Last Page: 2631
DOI: 10.1016/j.bmcl.2019.07.047

Target ChEMBL ID: CHEMBL4483269
ChEMBL Target Name: SUM-159-PT
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Non-Toxic

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：SUM-159-PT

External ID: CHEMBL4387578

Protocol: N/A

Comment: Journal: Bioorg Med Chem Lett
Year: 2019
Volume: 29
Issue: 18
First Page: 2626
Last Page: 2631
DOI: 10.1016/j.bmcl.2019.07.047

Target ChEMBL ID: CHEMBL4483269
ChEMBL Target Name: SUM-159-PT
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Non-Toxic

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Pyrroline-5-carboxylate reductase 1, mitochondrial

External ID: CHEMBL4387580

Protocol: N/A

Comment: Journal: Bioorg Med Chem Lett
Year: 2019
Volume: 29
Issue: 18
First Page: 2626
Last Page: 2631
DOI: 10.1016/j.bmcl.2019.07.047

Target ChEMBL ID: CHEMBL4296002
ChEMBL Target Name: Pyrroline-5-carboxylate reductase 1, mitochondrial
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Units	Activity Comment
Inhibition	%	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Pyrroline-5-carboxylate reductase 1, mitochondrial

External ID: CHEMBL4387581

Protocol: N/A

Comment: Journal: Bioorg Med Chem Lett
Year: 2019
Volume: 29
Issue: 18
First Page: 2626
Last Page: 2631
DOI: 10.1016/j.bmcl.2019.07.047

Target ChEMBL ID: CHEMBL4296002
ChEMBL Target Name: Pyrroline-5-carboxylate reductase 1, mitochondrial
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	40	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Pyrroline-5-carboxylate reductase 1, mitochondrial

External ID: CHEMBL4387582

Protocol: N/A

Comment: Journal: Bioorg Med Chem Lett
Year: 2019
Volume: 29
Issue: 18
First Page: 2626
Last Page: 2631
DOI: 10.1016/j.bmcl.2019.07.047

Target ChEMBL ID: CHEMBL4296002
ChEMBL Target Name: Pyrroline-5-carboxylate reductase 1, mitochondrial
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	30	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Pyrroline-5-carboxylate reductase 1, mitochondrial

External ID: CHEMBL4387583

Protocol: N/A

Comment: Journal: Bioorg Med Chem Lett
Year: 2019
Volume: 29
Issue: 18
First Page: 2626
Last Page: 2631
DOI: 10.1016/j.bmcl.2019.07.047

Target ChEMBL ID: CHEMBL4296002
ChEMBL Target Name: Pyrroline-5-carboxylate reductase 1, mitochondrial
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Units	Activity Comment
Inhibition	%	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Pyrroline-5-carboxylate reductase 1, mitochondrial

External ID: CHEMBL4387584

Protocol: N/A

Comment: Journal: Bioorg Med Chem Lett
Year: 2019
Volume: 29
Issue: 18
First Page: 2626
Last Page: 2631
DOI: 10.1016/j.bmcl.2019.07.047

Target ChEMBL ID: CHEMBL4296002
ChEMBL Target Name: Pyrroline-5-carboxylate reductase 1, mitochondrial
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Units	Activity Comment
Inhibition	%	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：SUM-159-PT

External ID: CHEMBL4387571

Protocol: N/A

Comment: Journal: Bioorg Med Chem Lett
Year: 2019
Volume: 29
Issue: 18
First Page: 2626
Last Page: 2631
DOI: 10.1016/j.bmcl.2019.07.047

Target ChEMBL ID: CHEMBL4483269
ChEMBL Target Name: SUM-159-PT
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Non-Toxic

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Pyrroline-5-carboxylate reductase 1, mitochondrial

External ID: CHEMBL4387572

Protocol: N/A

Comment: Journal: Bioorg Med Chem Lett
Year: 2019
Volume: 29
Issue: 18
First Page: 2626
Last Page: 2631
DOI: 10.1016/j.bmcl.2019.07.047

Target ChEMBL ID: CHEMBL4296002
ChEMBL Target Name: Pyrroline-5-carboxylate reductase 1, mitochondrial
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	50	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：SUM-159-PT

External ID: CHEMBL4387573

Protocol: N/A

Comment: Journal: Bioorg Med Chem Lett
Year: 2019
Volume: 29
Issue: 18
First Page: 2626
Last Page: 2631
DOI: 10.1016/j.bmcl.2019.07.047

Target ChEMBL ID: CHEMBL4483269
ChEMBL Target Name: SUM-159-PT
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Non-Toxic

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：SUM-159-PT

External ID: CHEMBL4387574

Protocol: N/A

Comment: Journal: Bioorg Med Chem Lett
Year: 2019
Volume: 29
Issue: 18
First Page: 2626
Last Page: 2631
DOI: 10.1016/j.bmcl.2019.07.047

Target ChEMBL ID: CHEMBL4483269
ChEMBL Target Name: SUM-159-PT
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Non-Toxic

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：SUM-159-PT

External ID: CHEMBL4387575

Protocol: N/A

Comment: Journal: Bioorg Med Chem Lett
Year: 2019
Volume: 29
Issue: 18
First Page: 2626
Last Page: 2631
DOI: 10.1016/j.bmcl.2019.07.047

Target ChEMBL ID: CHEMBL4483269
ChEMBL Target Name: SUM-159-PT
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Non-Toxic

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：SUM-159-PT

External ID: CHEMBL4387576

Protocol: N/A

Comment: Journal: Bioorg Med Chem Lett
Year: 2019
Volume: 29
Issue: 18
First Page: 2626
Last Page: 2631
DOI: 10.1016/j.bmcl.2019.07.047

Target ChEMBL ID: CHEMBL4483269
ChEMBL Target Name: SUM-159-PT
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Non-Toxic

709-85-3 靶点实验数据