S-(p-硝基苄基)谷胱甘肽结构式
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常用名 | S-(p-硝基苄基)谷胱甘肽 | 英文名 | Glycine, L-g-glutamyl-S-[(4-nitrophenyl)methyl]-L-cysteinyl- |
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| CAS号 | 6803-19-6 | 分子量 | 442.44400 | |
| 密度 | 1.464g/cm3 | 沸点 | 877.1ºC at 760 mmHg | |
| 分子式 | C17H22N4O8S | 熔点 | N/A | |
| MSDS | N/A | 闪点 | 484.2ºC |
S-(p-硝基苄基)谷胱甘肽用途S-(对硝基苄基)谷胱甘肽是一种竞争性谷胱甘肽硫酶抑制剂。S-(对硝基苄基)谷胱甘肽被大鼠肾微粒体转化为相应的半胱氨酸衍生物。S-(对硝基苄基)谷胱甘肽可用于谷胱甘肽被谷胱甘肽硫酶系统代谢分解的研究[1][2]。 |
| 中文名 | S-(p-硝基苄基)谷胱甘肽 |
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| 英文名 | S-(4-nitrobenzyl)glutathione |
| 英文别名 | 更多 |
| 密度 | 1.464g/cm3 |
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| 沸点 | 877.1ºC at 760 mmHg |
| 分子式 | C17H22N4O8S |
| 分子量 | 442.44400 |
| 闪点 | 484.2ºC |
| 精确质量 | 442.11600 |
| PSA | 229.94000 |
| LogP | 1.71100 |
| 折射率 | 1.618 |
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Molecular structure at 1.8 A of mouse liver class pi glutathione S-transferase complexed with S-(p-nitrobenzyl)glutathione and other inhibitors.
J. Mol. Biol. 237(3) , 298-314, (1994) The three-dimensional crystal structure of pi class glutathione S-transferase YfYf from mouse liver complexed with the inhibitor S-(p-nitrobenzyl)glutathione has been determined at 1.8 A resolution by... |
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The three-dimensional structure of Cys-47-modified mouse liver glutathione S-transferase P1-1. Carboxymethylation dramatically decreases the affinity for glutathione and is associated with a loss of electron density in the alphaB-310B region.
J. Biol. Chem. 273(5) , 2844-50, (1998) The three-dimensional structure of mouse liver glutathione S-transferase P1-1 carboxymethylated at Cys-47 and its complex with S-(p-nitrobenzyl)glutathione have been determined by x-ray diffraction an... |
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Site-directed mutagenesis of mouse glutathione transferase P1-1 unlocks masked cooperativity, introduces a novel mechanism for 'ping pong' kinetic behaviour, and provides further structural evidence for participation of a water molecule in proton abstraction from glutathione.
FEBS J. 278(2) , 273-81, (2011) Mouse liver glutathione transferase P1-1 has three cysteine residues at positions 14, 47 and 169. We have constructed the single, double and triple cysteine to alanine mutants to define the behaviour ... |
| s-(p-nitrobenzyl)glutathione |
