Glycine, L-g-glutamyl-S-[(4-nitrophenyl)methyl]-L-cysteinyl-
Modify Date: 2024-01-02 18:15:36
![Glycine, L-g-glutamyl-S-[(4-nitrophenyl)methyl]-L-cysteinyl- Structure](https://www.chemsrc.com/caspic/117/6803-19-6.png)
Glycine, L-g-glutamyl-S-[(4-nitrophenyl)methyl]-L-cysteinyl- structure
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Common Name | Glycine, L-g-glutamyl-S-[(4-nitrophenyl)methyl]-L-cysteinyl- | ||
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| CAS Number | 6803-19-6 | Molecular Weight | 442.44400 | |
| Density | 1.464g/cm3 | Boiling Point | 877.1ºC at 760 mmHg | |
| Molecular Formula | C17H22N4O8S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 484.2ºC | |
Use of Glycine, L-g-glutamyl-S-[(4-nitrophenyl)methyl]-L-cysteinyl-S-(p-Nitrobenzyl)glutathione is a competitive glutathionase inhibitor. S-(p-Nitrobenzyl)glutathione is converted to the corresponding cysteine derivatives by rat kidney microsomes. S-(p-Nitrobenzyl)glutathione can be used for the research of metabolic breakdown of glutathione by the glutathionase system[1][2]. |
| Name | S-(4-nitrobenzyl)glutathione |
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| Synonym | More Synonyms |
| Description | S-(p-Nitrobenzyl)glutathione is a competitive glutathionase inhibitor. S-(p-Nitrobenzyl)glutathione is converted to the corresponding cysteine derivatives by rat kidney microsomes. S-(p-Nitrobenzyl)glutathione can be used for the research of metabolic breakdown of glutathione by the glutathionase system[1][2]. |
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| Related Catalog |
| Density | 1.464g/cm3 |
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| Boiling Point | 877.1ºC at 760 mmHg |
| Molecular Formula | C17H22N4O8S |
| Molecular Weight | 442.44400 |
| Flash Point | 484.2ºC |
| Exact Mass | 442.11600 |
| PSA | 229.94000 |
| LogP | 1.71100 |
| Index of Refraction | 1.618 |
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Version 1.0
Regulation (EC) No 1907/2006 1 - Product and Company Information Product NameS-(P-NITROBENZYL)GLUTATHIONE 2 - Hazards Identification 3 - Composition/Information on Ingredients Product NameCAS #EC noAnnex I Index Number S-(P-NITROBENZYL)GLUTATHIONE6803-19-6 NoneNone FormulaC17H22N4O8S Molecular Weight 442,5000 AMU 4 - First Aid Measures 5 - Fire Fighting Measures 6 - Accidental Release Measures 7 - Handling and Storage STORAGE Store at 2-8°C 8 - Exposure Controls / Personal Protection 9 - Physical and Chemical Properties pH N/A BP/BP RangeN/A MP/MP RangeN/A Flash PointN/A FlammabilityN/A SIGMAwww.molbase.com Autoignition TempN/A Oxidizing Properties N/A Explosive Properties N/A Explosion LimitsN/A Vapor PressureN/A Partition Coefficient N/A ViscosityN/A Vapor DensityN/A Saturated Vapor Conc. N/A Evaporation RateN/A Bulk DensityN/A Decomposition Temp.N/A Solvent ContentN/A Water ContentN/A Surface TensionN/A ConductivityN/A Miscellaneous DataN/A SolubilityN/A 10 - Stability and Reactivity 11 - Toxicological Information 12 - Ecological Information No data available. 13 - Disposal Considerations 14 - Transport Information RID/ADR Non-hazardous for road transport. IMDG Non-hazardous for sea transport. IATA Non-hazardous for air transport. 15 - Regulatory Information Caution: Substance not yet fully tested (EU). COUNTRY SPECIFIC INFORMATION Germany WGK: 3 Self-Classification 16 - Other Information WARRANTY The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to SIGMAwww.molbase.com appropriate safety precautions. It does not represent any guarantee of the properties of the product. Inc., shall not be held liable for any damage resulting from handling or from contact with the above product. See reverse side of invoice or packing slip for additional terms and conditions of sale. Copyright 2010 Co. License granted to make unlimitedpaper copies for internal use only. DISCLAIMER For R&D use only. Not for drug, household or other uses. SIGMAwww.molbase.com SECTION 16 - ADDITIONAL INFORMATION N/A |
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Molecular structure at 1.8 A of mouse liver class pi glutathione S-transferase complexed with S-(p-nitrobenzyl)glutathione and other inhibitors.
J. Mol. Biol. 237(3) , 298-314, (1994) The three-dimensional crystal structure of pi class glutathione S-transferase YfYf from mouse liver complexed with the inhibitor S-(p-nitrobenzyl)glutathione has been determined at 1.8 A resolution by... |
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The three-dimensional structure of Cys-47-modified mouse liver glutathione S-transferase P1-1. Carboxymethylation dramatically decreases the affinity for glutathione and is associated with a loss of electron density in the alphaB-310B region.
J. Biol. Chem. 273(5) , 2844-50, (1998) The three-dimensional structure of mouse liver glutathione S-transferase P1-1 carboxymethylated at Cys-47 and its complex with S-(p-nitrobenzyl)glutathione have been determined by x-ray diffraction an... |
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Site-directed mutagenesis of mouse glutathione transferase P1-1 unlocks masked cooperativity, introduces a novel mechanism for 'ping pong' kinetic behaviour, and provides further structural evidence for participation of a water molecule in proton abstraction from glutathione.
FEBS J. 278(2) , 273-81, (2011) Mouse liver glutathione transferase P1-1 has three cysteine residues at positions 14, 47 and 169. We have constructed the single, double and triple cysteine to alanine mutants to define the behaviour ... |
| s-(p-nitrobenzyl)glutathione |